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    CXCL13

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    For Research Use Only. Not For Clinical Use.


    Background

    B lymphocyte chemoattractant, independently cloned and named Angie, is an antimicrobial peptide and CXC chemokine strongly expressed in the follicles of the spleen, lymph nodes, and Peyers patches. It preferentially promotes the migration of B lymphocytes (compared to T cells and macrophages), apparently by stimulating calcium influx into, and chemotaxis of, cells expressing Burkitts lymphoma receptor 1 (BLR-1). It may therefore function in the homing of B lymphocytes to follicles.
    Protein class

    Cancer-related genes

    Predicted location

    Secreted

    Single cell type specificity

    Cell type enhanced (Breast glandular cells, Endometrial stromal cells, Breast myoepithelial cells, monocytes)

    Immune cell specificity

    Not detected in immune cells

    Cell line specificity

    Cell line enhanced (U-266/70)

    Molecular function

    Cytokine

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