Human Anti-CXCL13 (clone W253B4) scFv-Fc Chimera (CAT#: VS-0125-FY12)

• Host Species
• Human

• Type
• Human IgG1, scFv-Fc

• Species Reactivity
• Human, Cynomolgus

• Clone
• W253B4

• Applications
• ELISA, Neutralization

• Related Disease
• Cancer

• Purity
• >95% as determined by SDS-PAGE

• Format
• Liquid

• Concentration
• Please refer to the vial label for the specific concentration.

• Buffer
• PBS

• Preservative
• No preservatives

• Stabilizer
• No Stabilizers

• Sterility
• 0.2 μM filtered

• Storage
• Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

• Shipping
• Ice packs

• Application Notes
• The anti-CXCL13 scFv-Fc is engineered to neutralize the chemokine CXCL13 by binding to it and preventing interaction with the CXCR5 receptor. This action plays a crucial role in modulating immune responses, as CXCL13 is known to recruit immune cells to inflamed or tumor sites. Additionally, its tetravalent bispecific format allows it to engage multiple targets, potentially enhancing therapeutic effectiveness through synergistic immune modulation. The design improvements made to the molecule focus on stability and manufacturability. These enhancements facilitate the formulation of the scFv-Fc in high concentrations. Consequently, it is suitable for subcutaneous delivery, which offers a more patient-friendly administration route compared to intravenous delivery. Overall, the anti-CXCL13 scFv-Fc holds promise in advancing immune therapies.

• Alternative Names
• C-X-C Motif Chemokine Ligand 13; Small Inducible Cytokine B Subfamily (Cys-X-Cys Motif), Member 13 (B-Cell Chemoattractant); B Cell-Attracting Chemokine 1; B Lymphocyte Chemoattractant; Small-Inducible Cytokine B13; B-Cell Chemoattractant; CXC Chemokine BLC; SCYB13; ANGIE; BCA-1; BCA1

• Gene ID
• 10563

• UniProt ID
• O43927

• Sequence Similarities
• Belongs to the intercrine alpha (chemokine CxC) family.

• Cellular Localization
• Secreted

• Post Translation Modifications
• Modification sites at PhosphoSitePlus
  Modification sites at neXtProt

• Protein Refseq
• NP_001358487.1; NP_006410.1

• Function
• Chemotactic for B-lymphocytes but not for T-lymphocytes, monocytes and neutrophils.
  Does not induce calcium release in B-lymphocytes.
  Binds to BLR1/CXCR5.

Secondary Antibody

• 2ND-029CQ
• Goat Anti-Human IgG Fc Antibody

Isotype Control

• MOB-200CQ
• Human IgG Fc Isotype Control Antibody

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