Human Anti-F9 (clone 10C12) scFv-Fc Chimera (CAT#: VS-0425-FY61)
This scFv-Fc construct targets F9 (Factor IX), a protein involved in blood coagulation. It may be used in research for cancer targeting or in studying hemophilia-related mechanisms due to F9's expression on certain cancer cells.
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RNA Expression
Figure 1 RNA cell line category: Not detected
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000101981-F9
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000101981-F9
Specifications
- Immunogen
- The immunogen used in the initial screening was a synthetic Factor IX Gla domain.
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Specificity
- The 10C12 antibody exhibits a strong binding affinity to both full-length Factor IX and its activated form, with a dissociation constant (Kd) of 1.6 nm. This antibody is highly specific for Factor IX and does not cross-react with other vitamin K-dependent proteins, even though the Gla domains of these proteins share sequence similarities.
- Species Reactivity
- Human
- Clone
- 10C12
- Applications
- Inhibition
- Related Disease
- Hemophilia B or Christmas disease
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- The optimal dilution concentration is determined by the experiment.
Target
- Alternative Names
- Coagulation Factor IX; Plasma Thromboplastic Component; Plasma Thromboplastin Component; Christmas Factor; EC 3.4.21.22; PTC; Christmas Disease; Hemophilia B; Factor IX F9
- Gene ID
- 2158
- UniProt ID
- P00740
- Long Name
- Coagulation Factor IX
- Sequence Similarities
- Belongs to the peptidase S1 family.
- Cellular Localization
- Secreted
- Post Translation Modifications
- Activated by factor XIa, which excises the activation peptide.
The propeptide can also be removed by snake venom protease.
The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.
Glycosylation at Thr85, Ser99, Ser107, Asn203, Thr205, Asn213, Thr215, and Thr225
Modification sites at PhosphoSitePlus
Glycosylation from GlyConnect FA9_HUMAN (96)
Glycosylation from GlyGen 10 sites, 23 N-linked glycans (1 site), 18 O-linked glycans (8 sites)
- Protein Refseq
- XP_005262454.1; XP_054182657.1; NP_000124.1; NP_001300842.1
- Function
- Factor IX is a vitamin K-dependent plasma protein that participates in the intrinsic pathway of blood coagulation by converting factor X to its active form in the presence of Ca(2+) ions, phospholipids, and factor VIIIa.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Antibody Magnetic Beads
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-347 | Recombinant Anti-human F9 Antibody | WB, IP, FuncS | IgG |
| MHH-347 | Recombinant Human Anti-human F9 Antibody | Neut, WB, FuncS | IgG |
| MOB-0368MZ | Recombinant Mouse Anti-Human Factor IX Antibody (clone BIJY-5042) | RIA, WB, ELISA | Mouse antibody |
| HPAB-0449-YJ | Mouse Anti-F9 Recombinant Antibody (clone 11B4-C3) | ELISA, IP, WB | Mouse IgG1, κ |
| VS-0224-XY45 | Mouse Anti-F9 Recombinant Antibody (clone 2C9) | ELISA, WB, IP | Mouse IgG1 |
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For Research Use Only. Not For Clinical Use.
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