Human Anti-F9 (clone 10C12) scFv-Fc Chimera (CAT#: VS-0425-FY61)
This scFv-Fc construct targets F9 (Factor IX), a protein involved in blood coagulation. It may be used in research for cancer targeting or in studying hemophilia-related mechanisms due to F9's expression on certain cancer cells.
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RNA Expression
Figure 1 RNA cell line category: Not detected
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000101981-F9
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000101981-F9
Specifications
- Immunogen
- The immunogen used in the initial screening was a synthetic Factor IX Gla domain.
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Specificity
- The 10C12 antibody exhibits a strong binding affinity to both full-length Factor IX and its activated form, with a dissociation constant (Kd) of 1.6 nm. This antibody is highly specific for Factor IX and does not cross-react with other vitamin K-dependent proteins, even though the Gla domains of these proteins share sequence similarities.
- Species Reactivity
- Human
- Clone
- 10C12
- Applications
- Inhibition
- Related Disease
- Hemophilia B or Christmas disease
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- The optimal dilution concentration is determined by the experiment.
Target
- Alternative Names
- Coagulation Factor IX; Plasma Thromboplastic Component; Plasma Thromboplastin Component; Christmas Factor; EC 3.4.21.22; PTC; Christmas Disease; Hemophilia B; Factor IX F9
- Gene ID
- 2158
- UniProt ID
- P00740
- Long Name
- Coagulation Factor IX
- Sequence Similarities
- Belongs to the peptidase S1 family.
- Cellular Localization
- Secreted
- Post Translation Modifications
- Activated by factor XIa, which excises the activation peptide.
The propeptide can also be removed by snake venom protease.
The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.
Glycosylation at Thr85, Ser99, Ser107, Asn203, Thr205, Asn213, Thr215, and Thr225
Modification sites at PhosphoSitePlus
Glycosylation from GlyConnect FA9_HUMAN (96)
Glycosylation from GlyGen 10 sites, 23 N-linked glycans (1 site), 18 O-linked glycans (8 sites)
- Protein Refseq
- XP_005262454.1; XP_054182657.1; NP_000124.1; NP_001300842.1
- Function
- Factor IX is a vitamin K-dependent plasma protein that participates in the intrinsic pathway of blood coagulation by converting factor X to its active form in the presence of Ca(2+) ions, phospholipids, and factor VIIIa.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Antibody Magnetic Beads
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-347 | Recombinant Anti-human F9 Antibody | WB, IP, FuncS | IgG |
| MHH-347 | Recombinant Human Anti-human F9 Antibody | Neut, WB, FuncS | IgG |
| MOB-0368MZ | Recombinant Mouse Anti-Human Factor IX Antibody (clone BIJY-5042) | RIA, WB, ELISA | Mouse antibody |
| HPAB-0449-YJ | Mouse Anti-F9 Recombinant Antibody (clone 11B4-C3) | ELISA, IP, WB | Mouse IgG1, κ |
| VS-0224-XY45 | Mouse Anti-F9 Recombinant Antibody (clone 2C9) | ELISA, WB, IP | Mouse IgG1 |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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