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F9

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This gene encodes vitamin K-dependent coagulation factor IX that circulates in the blood as an inactive zymogen. This factor is converted to an active form by factor XIa, which excises the activation peptide and thus generates a heavy chain and a light chain held together by one or more disulfide bonds. The role of this activated factor IX in the blood coagulation cascade is to activate factor X to its active form through interactions with Ca+2 ions, membrane phospholipids, and factor VIII. Alterations of this gene, including point mutations, insertions and deletions, cause factor IX deficiency, which is a recessive X-linked disorder, also called hemophilia B or Christmas disease. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing.

Derivation:
Mouse
Species Reactivity:
Human
Type:
IgG
Application:
WB, IP, FuncS
Derivation:
Mouse
Species Reactivity:
Human
Type:
Fab
Application:
WB, RIA, FuncS
Derivation:
Mouse
Species Reactivity:
Human
Type:
scFv
Application:
RIA, ELISA, FuncS
Species Reactivity:
Human
Type:
Mouse antibody
Application:
ELISA, WB
Species Reactivity:
Human, Bovine
Type:
Mouse IgG
Application:
WB, ELISA
Species Reactivity:
Human, Rat, Cynomolgus monkey
Type:
Mouse IgG2a
Application:
ELISA, BL
Derivation:
Humanized
Species Reactivity:
Human, Rat, Cynomolgus monkey
Type:
Humanized IgG1, κ
Application:
ELISA, BL
Derivation:
Chimeric (Mouse/Human)
Species Reactivity:
Human, Rat, Cynomolgus monkey
Type:
Chimeric (Mouse/Human) IgG
Application:
ELISA, BL
Species Reactivity:
Human
Type:
Mouse IgG
Application:
WB, ELISA
Species Reactivity:
Human
Type:
Mouse IgG
Application:
WB, ELISA
Species Reactivity:
Human
Type:
Mouse IgG
Application:
WB, ELISA
Species Reactivity:
Human, Bovine
Type:
Mouse scFv
Application:
WB, ELISA
Species Reactivity:
Human, Rat, Cynomolgus monkey
Type:
Mouse scFv
Application:
ELISA, BL
Derivation:
Humanized
Species Reactivity:
Human, Rat, Cynomolgus monkey
Type:
Humanized scFv
Application:
ELISA, BL
Species Reactivity:
Human, Rat, Cynomolgus monkey
Type:
scFv
Application:
ELISA, BL
Species Reactivity:
Human
Type:
Mouse scFv
Application:
WB, ELISA
Species Reactivity:
Human
Type:
Mouse scFv
Application:
WB, ELISA
Species Reactivity:
Human
Type:
Mouse scFv
Application:
WB, ELISA
Species Reactivity:
Human, Bovine
Type:
Mouse Fab
Application:
WB, ELISA
Species Reactivity:
Human, Rat, Cynomolgus monkey
Type:
Mouse Fab
Application:
ELISA, BL
Derivation:
Humanized
Species Reactivity:
Human, Rat, Cynomolgus monkey
Type:
Humanized Fab
Application:
ELISA, BL
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