Human Anti-GPC1 (clone K090-01a002) scFv-Fc Chimera
CAT#: VS-0325-FY22
The Anti-GPC1 scFv-Fc antibody is a novel therapeutic and diagnostic tool designed to specifically bind to Glypican-1, a heparan sulfate proteoglycan implicated in various biological processes, including cell growth, differentiation, and cancer progression. This antibody format combines the specificity of an scFv with the stability and extended serum half-life of an Fc region, enhancing its therapeutic potential.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line HaCaT
Immunofluorescent staining of human cell line HaCaT shows localization to plasma membrane & cytosol.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/30571/1715_D1_13_cr57fd06304494c_selected.jpg
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Specifications
- Immunogen
- A recombinant human GPC1 protein.
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Specificity
- Human GPC1
- Species Reactivity
- Human
- Clone
- K090-01a002
- Applications
- ADC, ELISA
- Related Disease
- Cancer
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Target
- Alternative Names
- Glypican 1; Glypican Proteoglycan 1; Glypican-1; Glypican
- Gene ID
- 2817
- UniProt ID
- P35052
- Long Name
- Glypican 1
- Sequence Similarities
- Belongs to the glypican family.
- Cellular Localization
- Cell membrane; Lipid-anchor, GPI-anchor; Extracellular side; Endosome
- Post Translation Modifications
- S-nitrosylated in a Cu(2+)-dependent manner.
Nitric acid is released from the nitrosylated cysteines by ascorbate or by some other reducing agent, in a Cu(2+) or Zn(2+) dependent manner.
This free nitric oxide is then capable of cleaving the heparan sulfate side chains.
N- and O-glycosylated.
N-glycosylation is mainly of the complex type containing sialic acid.
O-glycosylated with heparan sulfate.
- Protein Refseq
- XP_047299917.1; NP_002072.2
- Function
- Cell surface proteoglycan that bears heparan sulfate.
Binds, via the heparan sulfate side chains, alpha-4 (V) collagen and participates in Schwann cell myelination (By similarity).
May act as a catalyst in increasing the rate of conversion of prion protein PRPN(C) to PRNP(Sc) via associating (via the heparan sulfate side chains) with both forms of PRPN, targeting them to lipid rafts and facilitating their interaction.
Required for proper skeletal muscle differentiation by sequestering FGF2 in lipid rafts preventing its binding to receptors (FGFRs) and inhibiting the FGF-mediated signaling.
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Isotype Control
- CAT
- Product Name
Secondary Antibody
- CAT
- Product Name
See other products for "GPC1"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NS-033CN | Human Anti-GPC1 Recombinant Antibody (NS-033CN) | WB, IF | Human IgG1 |
| NS-033CN-F(E) | Human Anti-GPC1 Recombinant Antibody; Fab Fragment (NS-033CN-F(E)) | WB, IF | Human Fab |
| NS-033CN-S(P) | Human Anti-GPC1 Recombinant Antibody; scFv Fragment (NS-033CN-S(P)) | WB, IF | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MRO-1903-CN | Rabbit Anti-GPC1 Polyclonal Antibody (MRO-1903-CN) | WB, IF, IHC, FC | Rabbit IgG |
| HPAB-0152-YJ | Mouse Anti-GPC1 Recombinant Antibody (HPAB-0152-YJ) | ELISA, WB | Mouse IgG1, κ |
| HPAB-0153-YJ | Mouse Anti-GPC1 Recombinant Antibody (HPAB-0153-YJ) | ELISA, WB | Mouse IgG1, κ |
| VS3-WK152 | Mouse Anti-GPC1 Recombinant Antibody (clone GP001) | WB, ELISA | Mouse IgG |
| VS3-WK153 | Mouse Anti-GPC1 Recombinant Antibody (clone GP002) | WB, ELISA | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0152-YJ-S(P) | Mouse Anti-GPC1 Recombinant Antibody; scFv Fragment (HPAB-0152-YJ-S(P)) | ELISA, WB | Mouse scFv |
| HPAB-0153-YJ-S(P) | Mouse Anti-GPC1 Recombinant Antibody; scFv Fragment (HPAB-0153-YJ-S(P)) | ELISA, WB | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0152-YJ-F(E) | Mouse Anti-GPC1 Recombinant Antibody; Fab Fragment (HPAB-0152-YJ-F(E)) | ELISA, WB | Mouse Fab |
| HPAB-0153-YJ-F(E) | Mouse Anti-GPC1 Recombinant Antibody; Fab Fragment (HPAB-0153-YJ-F(E)) | ELISA, WB | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0125-FY60 | Mouse Anti-GPC1 scFv-Fc Chimera (VS-0125-FY60) | FC, IHC, IF | Mouse IgG2a, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC623 | Recombinant Anti-GPC1 Vesicular Antibody, EV Displayed (VS-0425-YC623) | ELISA, FC, Cell-uptake |
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