Human Anti-GPC1 (clone K090-01a002) scFv-Fc Chimera (CAT#: VS-0325-FY22)
The Anti-GPC1 scFv-Fc antibody is a novel therapeutic and diagnostic tool designed to specifically bind to Glypican-1, a heparan sulfate proteoglycan implicated in various biological processes, including cell growth, differentiation, and cancer progression. This antibody format combines the specificity of an scFv with the stability and extended serum half-life of an Fc region, enhancing its therapeutic potential.
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Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line HaCaT
(Immunofluorescent staining of human cell line HaCaT shows localization to plasma membrane & cytosol.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/30571/1715_D1_13_cr57fd06304494c_selected.jpg
(Immunofluorescent staining of human cell line HaCaT shows localization to plasma membrane & cytosol.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/30571/1715_D1_13_cr57fd06304494c_selected.jpg
Figure 2 IHC staining of human duodenum
(Immunohistochemical staining of human duodenum shows moderate positivity in luminal membrane.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/30571/ihc_selected.jpg
(Immunohistochemical staining of human duodenum shows moderate positivity in luminal membrane.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/30571/ihc_selected.jpg
Figure 3 Skin 1
(High expression in skin 1)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/70449/169210_B_8_1_val_selected.jpg
(High expression in skin 1)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/70449/169210_B_8_1_val_selected.jpg
Figure 4 Cerebral cortex
(Endothelial cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/30571/64142_B_7_5.jpg
(Endothelial cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/30571/64142_B_7_5.jpg
Figure 5 Colon
(Endothelial cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Glandular cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/30571/64142_A_8_3.jpg
(Endothelial cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Glandular cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/30571/64142_A_8_3.jpg
Figure 6 Testis
(Leydig cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Sertoli cells Staining: Medium Intensity: Moderate Quantity: 75%-25%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/30571/64142_A_4_6.jpg
(Leydig cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Sertoli cells Staining: Medium Intensity: Moderate Quantity: 75%-25%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/30571/64142_A_4_6.jpg
Figure 7 RNA cell line category: Low cell line specificity
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000063660-GPC1
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000063660-GPC1
Specifications
- Immunogen
- A recombinant human GPC1 protein.
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Specificity
- Human GPC1
- Species Reactivity
- Human
- Clone
- K090-01a002
- Applications
- ADC, ELISA
- Related Disease
- Cancer
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Target
- Alternative Names
- Glypican 1; Glypican Proteoglycan 1; Glypican-1; Glypican
- Gene ID
- 2817
- UniProt ID
- P35052
- Long Name
- Glypican 1
- Sequence Similarities
- Belongs to the glypican family.
- Cellular Localization
- Cell membrane; Lipid-anchor, GPI-anchor; Extracellular side; Endosome
- Post Translation Modifications
- S-nitrosylated in a Cu(2+)-dependent manner.
Nitric acid is released from the nitrosylated cysteines by ascorbate or by some other reducing agent, in a Cu(2+) or Zn(2+) dependent manner.
This free nitric oxide is then capable of cleaving the heparan sulfate side chains.
N- and O-glycosylated.
N-glycosylation is mainly of the complex type containing sialic acid.
O-glycosylated with heparan sulfate.
- Protein Refseq
- XP_047299917.1; NP_002072.2
- Function
- Cell surface proteoglycan that bears heparan sulfate.
Binds, via the heparan sulfate side chains, alpha-4 (V) collagen and participates in Schwann cell myelination (By similarity).
May act as a catalyst in increasing the rate of conversion of prion protein PRPN(C) to PRNP(Sc) via associating (via the heparan sulfate side chains) with both forms of PRPN, targeting them to lipid rafts and facilitating their interaction.
Required for proper skeletal muscle differentiation by sequestering FGF2 in lipid rafts preventing its binding to receptors (FGFRs) and inhibiting the FGF-mediated signaling.
Recommended Products
Isotype Control
Secondary Antibody
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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Extracellular Vesicle (EV) Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NS-033CN | Human Anti-GPC1 Recombinant Antibody (NS-033CN) | WB, IF | Human IgG1 |
| NS-033CN-F(E) | Human Anti-GPC1 Recombinant Antibody; Fab Fragment (NS-033CN-F(E)) | WB, IF | Human Fab |
| NS-033CN-S(P) | Human Anti-GPC1 Recombinant Antibody; scFv Fragment (NS-033CN-S(P)) | WB, IF | Human scFv |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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