Mouse Anti-GPC1 scFv-Fc Chimera (VS-0125-FY60) (CAT#: VS-0125-FY60)

• Host Species
• Mouse

• Type
• Mouse IgG2a, scFv-Fc

• Species Reactivity
• Human

• Applications
• Flow Cytometry, Immunohistochemistry, Immunofluorescence

• Related Disease
• Cancer

• Purity
• >95% as determined by SDS-PAGE

• Format
• Liquid

• Concentration
• Please refer to the vial label for the specific concentration.

• Buffer
• PBS

• Preservative
• No preservatives

• Stabilizer
• No Stabilizers

• Sterility
• 0.2 μM filtered

• Storage
• Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

• Shipping
• Ice packs

• Application Notes
• The anti-GPC1 scFv-Fc fusion protein has the potential to selectively bind to GPC1, providing a means to assess its expression in various cells or tissues. Utilizing this fusion protein in techniques such as flow cytometry (FACS), fluorescence microscopy, and immunohistochemical staining allows for the precise detection of GPC1 expression. This capability may facilitate the evaluation of GPC1 expression levels in tumor cells, offering insights into its role in cancer biology.

• Alternative Names
• Glypican 1; Glypican Proteoglycan 1; Glypican-1; Glypican

• Gene ID
• 2817

• UniProt ID
• P35052

• Sequence Similarities
• Belongs to the glypican family.

• Cellular Localization
• Cell membrane; Lipid-anchor, GPI-anchor; Extracellular side
  Endosome

• Post Translation Modifications
• S-nitrosylated in a Cu(2+)-dependent manner.
  N- and O-glycosylated.
  This cell-associated glypican is further processed to give rise to a medium-released species.
  Glycosylation at Asn79, Asn116, Ser486, Ser488, Ser490, Thr512, and Thr515
  Modification sites at PhosphoSitePlus
  Glycosylation from GlyConnect GPC1_HUMAN (1279)
  Glycosylation from GlyGen 13 sites, 15 N-linked glycans (2 sites), 3 O-linked glycans (7 sites)

• Protein Refseq
• XP_047299917.1; NP_002072.2

• Function
• Cell surface proteoglycan that bears heparan sulfate.
  Binds, via the heparan sulfate side chains, alpha-4 (V) collagen and participates in Schwann cell myelination (By similarity).
  May act as a catalyst in increasing the rate of conversion of prion protein PRPN(C) to PRNP(Sc) via associating (via the heparan sulfate side chains) with both forms of PRPN, targeting them to lipid rafts and facilitating their interaction.

Secondary Antibody

• 2ND-029CQ
• Goat Anti-Human IgG Fc Antibody

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