Human Anti-IL5RA (clone KM1399) scFv-Fc Chimera
CAT#: VS-0425-FY76
This fusion protein targets IL5RA (IL-5 receptor alpha), which is involved in eosinophil activation and survival. It is being explored for its potential use in treating allergic and inflammatory conditions by inhibiting IL-5 signaling.
Gene Expression
RNA Expression
Figure 1 RNA cell line category: Cell line enriched (HMC-1)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000091181-IL5RA
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Specifications
- Immunogen
- Human IL-5Rα as an immunogen.
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Specificity
- Human IL5RA
- Species Reactivity
- Human
- Clone
- KM1399
- Applications
- ELISA, Inhibition, Immunoprecipitation
- Related Disease
- Pancreatic Vasoactive Intestinal Peptide Producing Tumor and Hypereosinophilic Syndrome
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- Immunoprecipitation: 0.01-50 μg/mL
ELISA: 40 μg/mL
The optimal dilution concentration is determined by the experiment.
Target
- Alternative Names
- Interleukin 5 Receptor Subunit Alpha
- Gene ID
- 3568
- UniProt ID
- Q01344
- Long Name
- Interleukin 5 Receptor Subunit Alpha
- Sequence Similarities
- Belongs to the type I cytokine receptor family. Type 5 subfamily.
- Cellular Localization
- Membrane
- Post Translation Modifications
- Glycosylation at Asn35, Asn131, Asn216, and Asn244
Modification sites at PhosphoSitePlus
Glycosylation from GlyGen 4 sites
- Protein Refseq
- XP_011531979.1; XP_011531980.1; XP_054202430.1; XP_054202431.1; NP_000555.2
- Function
- Cell surface receptor that plays an important role in the survival, differentiation, and chemotaxis of eosinophils.
Acts by forming a heterodimeric receptor with CSF2RB subunit and subsequently binding to interleukin-5.
In unstimulated conditions, interacts constitutively with JAK2.
Heterodimeric receptor activation leads to JAK2 stimulation and subsequent activation of the JAK-STAT pathway.
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "Clone KM1399"
- CAT
- Product Name
See other products for "IL5RA"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2473z | Mouse Anti-IL5RA Recombinant Antibody (clone 33H12) | WB, FC | Mouse IgG1 |
| HPAB-1545WJ | Human Anti-IL5RA Recombinant Antibody (clone KM1399) | ELISA, WB | Human IgG1, κ |
| VS-0723-WK142 | Human Anti-IL5RA Recombinant Antibody (VS-0723-WK142) | FC | Chimeric (rabbit/human) IgG1 |
| VS13-YC584 | Rabbit Anti-IL5RA Recombinant Antibody (VS13-YC584) | IHC-P | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-222 | Anti-Human IL5RA Recombinant Antibody (TAB-222) | WB, FC, IP, ELISA, Neut, FuncS, IF | IgG1 - kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1813 | Rabbit Anti-IL5RA Recombinant Antibody (clone DS1813AB) | WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-222 | Afuco™ Anti-IL5RA ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-222) | FC, IP, ELISA, Neut, FuncS | ADCC enhanced antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-1545WJ-F(E) | Human Anti-IL5RA Recombinant Antibody; Fab Fragment (clone KM1399) | ELISA, WB | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-1545WJ-S(P) | Human Anti-IL5RA Recombinant Antibody; scFv Fragment (clone KM1399) | ELISA, WB | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC205 | Recombinant Anti-IL5RA Vesicular Antibody, EV Displayed (VS-0425-YC205) | ELISA, FC, Neut, Cell-uptake |
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