Human Anti-IL5RA (clone KM1399) scFv-Fc Chimera (CAT#: VS-0425-FY76)
This fusion protein targets IL5RA (IL-5 receptor alpha), which is involved in eosinophil activation and survival. It is being explored for its potential use in treating allergic and inflammatory conditions by inhibiting IL-5 signaling.
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RNA Expression
Figure 1 RNA cell line category: Cell line enriched (HMC-1)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000091181-IL5RA
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000091181-IL5RA
Specifications
- Immunogen
- Human IL-5Rα as an immunogen.
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Specificity
- Human IL5RA
- Species Reactivity
- Human
- Clone
- KM1399
- Applications
- ELISA, Inhibition, Immunoprecipitation
- Related Disease
- Pancreatic Vasoactive Intestinal Peptide Producing Tumor and Hypereosinophilic Syndrome
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- Immunoprecipitation: 0.01-50 μg/mL
ELISA: 40 μg/mL
The optimal dilution concentration is determined by the experiment.
Target
- Alternative Names
- Interleukin 5 Receptor Subunit Alpha
- Gene ID
- 3568
- UniProt ID
- Q01344
- Long Name
- Interleukin 5 Receptor Subunit Alpha
- Sequence Similarities
- Belongs to the type I cytokine receptor family. Type 5 subfamily.
- Cellular Localization
- Membrane
- Post Translation Modifications
- Glycosylation at Asn35, Asn131, Asn216, and Asn244
Modification sites at PhosphoSitePlus
Glycosylation from GlyGen 4 sites
- Protein Refseq
- XP_011531979.1; XP_011531980.1; XP_054202430.1; XP_054202431.1; NP_000555.2
- Function
- Cell surface receptor that plays an important role in the survival, differentiation, and chemotaxis of eosinophils.
Acts by forming a heterodimeric receptor with CSF2RB subunit and subsequently binding to interleukin-5.
In unstimulated conditions, interacts constitutively with JAK2.
Heterodimeric receptor activation leads to JAK2 stimulation and subsequent activation of the JAK-STAT pathway.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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Extracellular Vesicle (EV) Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2473z | Mouse Anti-IL5RA Recombinant Antibody (clone 33H12) | WB, FC | Mouse IgG1 |
| HPAB-1545WJ | Human Anti-IL5RA Recombinant Antibody (clone KM1399) | ELISA, WB | Human IgG1, κ |
| VS-0723-WK142 | Human Anti-IL5RA Recombinant Antibody (VS-0723-WK142) | FC | Chimeric (rabbit/human) IgG1 |
| VS13-YC584 | Rabbit Anti-IL5RA Recombinant Antibody (VS13-YC584) | IHC-P | Rabbit IgG |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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