Human Anti-LILRA4 scFv-Fc Chimera (VS-0325-FY103)
CAT#: VS-0325-FY103
The anti-LILRA4 scFv-Fc antibody is designed to specifically target LILRA4, a receptor involved in immune regulation. It is engineered with a scFv-Fc format to enhance stability and prolong half-life in vivo. This antibody can be used in both in vitro and in vivo studies to explore the role of LILRA4 in diseases like cancer and autoimmune disorders.
Gene Expression
Subcellular Location and Protein Expression
Figure 1 IHC staining of human lymph node
Immunohistochemical staining of human lymph node shows strong cytoplasmic positivity in non-germinal center cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/49418/118151_A_7_8_selected.jpg
Normal Tissue
Figure 2 Colon
Glandular cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/49418/118151_A_7_3.jpg
Normal Tissue
Figure 3 Kidney
Cells in glomeruli
Staining: Not detected
Intensity: Weak
Quantity: <25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/49418/118151_A_7_5.jpg
Normal Tissue
Figure 4 Testis
Elongated or late spermatids
Staining: High
Intensity: Strong
Quantity:>75%
Round or early spermatids
Staining: High
Intensity: Strong
Quantity:>75%
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/49418/118151_A_5_6.jpg
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Specifications
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Specificity
- Human LILRA4
- Species Reactivity
- Human
- Applications
- Flow Cytometry
- Related Disease
- Cancer, autoimmune disease
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Target
- Alternative Names
- ILT7; CD85g
- Gene ID
- 23547
- Long Name
- leukocyte immunoglobulin like receptor A4
- Cellular Localization
- Cell membrane
- Post Translation Modifications
- Glycosylation at Asn138, Asn239, Asn279, and Asn300
Modification sites at PhosphoSitePlus
Glycosylation from GlyGen 4 sites
- Protein Refseq
- NP_036408.4
- Function
- Functions coreceptor to limit the innate immune responses to viral infections; signaling occurs via FCER1G (PubMed:16735691, 19564354).
Down-regulates the production of IFNA1, IFNA2, IFNA4, IFNB1 and TNF by plasmacytoid dendritic cells that have been exposed to influenza virus or cytidine-phosphate-guanosine (CpG) dinucleotides, indicating it functions as a negative regulator of TLR7 and TLR9 signaling cascades.
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Downloadable Resources
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Isotype Control
- CAT
- Product Name
Secondary Antibody
- CAT
- Product Name
See other products for "LILRA4"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1095CT | Recombinant Mouse anti-Human LILRA4 Monoclonal antibody (28H20.3) | FC | |
| FN-194CQ | Recombinant Mouse Anti-LILRA4 Antibody (17G10.2) | FC, FuncS, IP | Mouse IgG1 |
| HPAB-N0168-YC | Human Anti-LILRA4 Recombinant Antibody (HPAB-N0168-YC) | FC, ELISA, FuncS | Humanized IgG1 |
| VS3-FY2605 | Mouse Anti-LILRA4 Recombinant Antibody (VS3-FY2605) | IHC, FC, ELISA | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-N0168-YC-S(P) | Human Anti-LILRA4 Recombinant Antibody; scFv Fragment (HPAB-N0168-YC-S(P)) | FC, ELISA, FuncS | Humanized scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-N0168-YC-F(E) | Human Anti-LILRA4 Recombinant Antibody; Fab Fragment (HPAB-N0168-YC-F(E)) | FC, ELISA, FuncS | Humanized Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC459 | Recombinant Anti-LILRA4 Vesicular Antibody, EV Displayed (VS-0425-YC459) | ELISA, FC, Cell-uptake |
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