Human Anti-LTA scFv-Fc Chimera (VS-0425-FY147)
CAT#: VS-0425-FY147
Anti-LTA scFv-FC specifically binds to lipoteichoic acid (LTA), a component of the bacterial cell wall. This scFv-FC format aims to neutralize LTA's effects, reducing inflammatory responses associated with bacterial infections. The Fc region extends the half-life and can facilitate mechanisms like antibody-dependent cellular cytotoxicity (ADCC), making it a candidate for therapeutic use in infectious diseases.
Gene Expression
Normal Tissue
Figure 1 Kidney
Cells in glomeruli
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Cells in tubules
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/7729/28404_A_7_5.jpg
Normal Tissue
Figure 2 Testis
Cells in seminiferous ducts
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
Leydig cells
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/7729/28404_A_5_6.jpg
RNA Expression
Figure 3 RNA cell line category: Cell line enhanced (JURKAT, MOLT-4)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000226979-LTA
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Specifications
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Specificity
- Human LTA
- Species Reactivity
- Human
- Applications
- Neutralization
- Related Disease
- Psoriatic Arthritis and Leprosy 4
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- The optimal dilution concentration is determined by the experiment.
Target
- Alternative Names
- LT; LTA; TNF-B; TNFSF1; Tumor Necrosis Factor Ligand Superfamily Member 1; Lymphotoxin Alpha
- Long Name
- Lymphotoxin Alpha
- Function
- Lipoteichoic acid (LTA) is a major surface component of Gram-positive bacteria, acting as a crucial structural molecule for cell wall integrity, growth, and division. Anchored in the bacterial membrane, it extends through the peptidoglycan layer.
Beyond its structural role, LTA is a potent modulator of the host immune system. It acts as a pathogen-associated molecular pattern (PAMP) recognized by pattern recognition receptors like Toll-like receptor 2 (TLR2) on immune cells. This recognition triggers signaling pathways leading to the release of pro-inflammatory cytokines, chemokines, and other immune mediators, playing a vital role in the initial response to Gram-positive bacterial infections. However, excessive LTA stimulation can also contribute to inflammation and tissue damage. The specific immune responses elicited by LTA can vary depending on its structural variations across different bacterial species.
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Related Signaling Pathways
TNF Signaling Pathway
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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| HPAB-0212-YC-F(E) | Human Anti-LTA Recombinant Antibody (clone 3F12.v5); Fab Fragment | ELISA, FC, Block | Humanized Fab |
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