Human Anti-TNFRSF14 (clone HM3.30) scFv-Fc Chimera (CAT#: VS-0425-FY39)
The anti-HVEM scFv-Fc is a recombinant protein designed to specifically target and bind to herpesvirus entry mediator (HVEM), a critical component in immune regulation. This fusion protein consists of a single-chain variable fragment (scFv) fused to an Fc region, enhancing its stability and half-life in circulation. The scFv component provides high specificity and affinity for HVEM, making it an ideal candidate for therapeutic applications in immuno-oncology. By blocking the HVEM pathway, this product may help to modulate immune responses and promote anti-tumor activity. Our rigorous purification process ensures high quality and consistency in every batch. This innovative therapeutic candidate holds great promise for advancing cancer treatment and enhancing immune responses.
Specific Inquiry
Custom Production
We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.
We require custom production
Normal Tissue
RNA Expression
Figure 1 Colon
(Glandular cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/30007/117736_A_7_3.jpg
(Glandular cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/30007/117736_A_7_3.jpg
Figure 2 Liver
(Cholangiocytes Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/30007/117736_A_9_4.jpg
(Cholangiocytes Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/30007/117736_A_9_4.jpg
Figure 3 Kidney
(Cells in tubules Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/30007/117736_A_7_5.jpg
(Cells in tubules Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/30007/117736_A_7_5.jpg
Figure 4 Lymph node
(Non-germinal center cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/30007/117736_A_8_8.jpg
(Non-germinal center cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/30007/117736_A_8_8.jpg
Figure 5 RNA cell line category: Cell line enhanced (SK-MEL-30)
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000157873-TNFRSF14
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000157873-TNFRSF14
Specifications
- Immunogen
- Mouse HVEM protein as an immunogen.
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Specificity
- Mouse HVEM
- Species Reactivity
- Mouse
- Clone
- HM3.30
- Applications
- Flow Cytometry, Immunohistochemistry
- Related Disease
- Herpes Simplex and Herpetic Whitlow
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- The optimal dilution concentration is determined by the experiment.
Target
- Alternative Names
- TNF Receptor Superfamily Member 14; Tumor Necrosis Factor Receptor Superfamily, Member 14 (Herpesvirus Entry Mediator); Herpes Virus Entry Mediator A; HVEA; HVEM; TR2; Tumor Necrosis Factor Receptor Superfamily, Member 14; Tumor Necrosis Factor Receptor Superfamily Member 14; Tumor Necrosis Factor Receptor-Like Gene2
- Gene ID
- 8764
- UniProt ID
- Q92956
- Long Name
- TNF Receptor Superfamily Member 14
- Sequence Similarities
- Belongs to the tumor necrosis factor receptor superfamily.
- Cellular Localization
- Cell membrane
- Post Translation Modifications
- N-glycosylated.
Glycosylation at Asn110 and Asn173
Modification sites at PhosphoSitePlus
Glycosylation from GlyGen 3 sites, 1 O-linked glycan (1 site)
- Protein Refseq
- XP_006711082.1; XP_011540685.1; XP_047289368.1; XP_047289369.1; XP_047289370.1
- Function
- May interact in cis (on the same cell) or in trans (on other cells) with BTLA.
In cis interactions, appears to play an immune regulatory role inhibiting in trans interactions in naive T cells to maintain a resting state.
In trans interactions, can predominate during adaptive immune response to provide survival signals to effector T cells.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "TNFRSF14"
Select a product category from the dropdown menu below to view related products.
Please select product type
IgG Antibody Products
Flow Cytometry (FC) related Reagents and Kits: Empowering Cell Function Research
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2448z | Mouse Anti-TNFRSF14 Recombinant Antibody (clone 44A9) | FC, ICC, IF, IP | Mouse IgG1 |
| MOB-2069CT | Recombinant Mouse anti-Human TNFRSF14 Monoclonal antibody (0.O.698) | FC, ICC/IF, IP | |
| FN-230CQ | Hamster Anti-Tnfrsf14 Recombinant Antibody (VMC214) | FC, FuncS, WB, IF | Hamster IgG |
Customer Reviews and Q&As
There are currently no Customer reviews or questions for VS-0425-FY39. Click the button above to contact us or submit your feedback about this product.
Popular products with customers
Application: Neut, ELISA, IF, IP, FuncS, FC, IHC
-1.png)
Application: ELISA, FC, IP, FuncS, IF, Neut, ICC
Application: WB, Neut, FuncS
Application: ELISA
-1.jpg)
Application: Neut, FC, IHC-Fr, IP, BA
Application: ELISA, FC, Inhib, FuncS
Application: ELISA, FC, FuncS
Application: ELISA, Inhib, FuncS
For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
Send Inquiry
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
