Human Anti-TNFRSF14 (clone HM3.30) scFv-Fc Chimera
CAT#: VS-0425-FY39
The anti-HVEM scFv-Fc is a recombinant protein designed to specifically target and bind to herpesvirus entry mediator (HVEM), a critical component in immune regulation. This fusion protein consists of a single-chain variable fragment (scFv) fused to an Fc region, enhancing its stability and half-life in circulation. The scFv component provides high specificity and affinity for HVEM, making it an ideal candidate for therapeutic applications in immuno-oncology. By blocking the HVEM pathway, this product may help to modulate immune responses and promote anti-tumor activity. Our rigorous purification process ensures high quality and consistency in every batch. This innovative therapeutic candidate holds great promise for advancing cancer treatment and enhancing immune responses.
Gene Expression
Normal Tissue
Figure 1 Colon
Glandular cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/30007/117736_A_7_3.jpg
Normal Tissue
Figure 2 Liver
Cholangiocytes Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/30007/117736_A_9_4.jpg
Normal Tissue
Figure 3 Kidney
Cells in tubules Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/30007/117736_A_7_5.jpg
Normal Tissue
Figure 4 Lymph node
Non-germinal center cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/30007/117736_A_8_8.jpg
RNA Expression
Figure 5 RNA cell line category: Cell line enhanced (SK-MEL-30)
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000157873-TNFRSF14
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Specifications
- Immunogen
- Mouse HVEM protein as an immunogen.
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Specificity
- Mouse HVEM
- Species Reactivity
- Mouse
- Clone
- HM3.30
- Applications
- Flow Cytometry, Immunohistochemistry
- Related Disease
- Herpes Simplex and Herpetic Whitlow
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- The optimal dilution concentration is determined by the experiment.
Target
- Alternative Names
- TNF Receptor Superfamily Member 14; Tumor Necrosis Factor Receptor Superfamily, Member 14 (Herpesvirus Entry Mediator); Herpes Virus Entry Mediator A; HVEA; HVEM; TR2; Tumor Necrosis Factor Receptor Superfamily, Member 14; Tumor Necrosis Factor Receptor Superfamily Member 14; Tumor Necrosis Factor Receptor-Like Gene2
- Gene ID
- 8764
- UniProt ID
- Q92956
- Long Name
- TNF Receptor Superfamily Member 14
- Sequence Similarities
- Belongs to the tumor necrosis factor receptor superfamily.
- Cellular Localization
- Cell membrane
- Post Translation Modifications
- N-glycosylated.
Glycosylation at Asn110 and Asn173
Modification sites at PhosphoSitePlus
Glycosylation from GlyGen 3 sites, 1 O-linked glycan (1 site)
- Protein Refseq
- XP_006711082.1; XP_011540685.1; XP_047289368.1; XP_047289369.1; XP_047289370.1
- Function
- May interact in cis (on the same cell) or in trans (on other cells) with BTLA.
In cis interactions, appears to play an immune regulatory role inhibiting in trans interactions in naive T cells to maintain a resting state.
In trans interactions, can predominate during adaptive immune response to provide survival signals to effector T cells.
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Downloadable Resources
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
See other products for "TNFRSF14"
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| CAT | Product Name | Application | Type |
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| MOB-2448z | Mouse Anti-TNFRSF14 Recombinant Antibody (clone 44A9) | FC, ICC, IF, IP | Mouse IgG1 |
| MOB-2069CT | Recombinant Mouse anti-Human TNFRSF14 Monoclonal antibody (0.O.698) | FC, ICC, IF, IP | |
| FN-230CQ | Hamster Anti-Tnfrsf14 Recombinant Antibody (VMC214) | FC, FuncS, WB, IF | Hamster IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0225-XY219 | CytoStream™ Mouse Anti-TNFRSF14 Recombinant Antibody (VS-0225-XY219) | FC | Mouse IgG1, kappa |
| VS13-YC1166 | CytoStream™ Rabbit Anti-TNFRSF14 Recombinant Antibody (VS13-YC1166) | FC, ELISA | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY7375 | Anti-TNFRSF14 Immunohistochemistry Kit | IHC |
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