+ Filter
Loading...
TNFRSF14
Anti-TNFRSF14 Recombinant Antibody Products
CompareMore Infomation
Can't find the products you're looking for? Try to filter in the left sidebar.Filter By Tag
More Infomation
Our customer service representatives are available 24 hours a day, from Monday to Sunday. Contact Us
For Research Use Only. Not For Clinical Use.
TNFRSF14, also called HVEM (herpesvirus entry mediator), is expressed on T cells, B cells, dendritic cells, and other cell types. It can interact with several ligands from the TNF superfamily and immunoglobulin superfamily. HVEM plays a role in regulating T - cell activation, co - stimulation, and immune cell - cell interactions. It can either promote or inhibit immune responses depending on the context. For example, in some cases, HVEM - ligand interactions can enhance T - cell activation, while in others, they can lead to immune suppression, and it is also involved in the entry of certain herpesviruses into cells.
Protein class
Cancer-related genes, CD markers, Human disease related genes
Predicted location
Intracellular, Membrane (different isoforms)
Single cell type specificity
Cell type enhanced (Proximal enterocytes)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Cell line enhanced (SK-MEL-30)
Interaction
Interacts with TRAF2, TRAF3 and TRAF5 (PubMed:9153189, PubMed:9162022). Interacts (via CRD1/TNFR-Cys 1) with CD160; this interaction is direct (PubMed:18193050, PubMed:23761635). Interacts with LTA and TNFSF14 (PubMed:9462508). Interacts (via CRD1/TNFR-Cys 1) in cis and trans with BTLA; the cis interactions inhibits the trans interactions (PubMed:19915044, PubMed:16169851). (Microbial infection) Interacts with herpes simplex virus 1/HHV-1 envelope glycoprotein D. (Microbial infection) Interacts with herpes simplex virus 2/HHV-2 envelope glycoprotein D.
Molecular function
Host cell receptor for virus entry, Receptor
More Types Infomation