anti-MIgG(Fc)-C-DMSA ADC (CAT#: ADC-1023-SMz)
This ADC product is composed of an anti-mouse IgG Fc specific polyclonal antibody conjugated via a cleavable linker to DMSA (anti-mouse IgG(Fc)-CL-DMSA). The antibody portion is a secondary antibody and the drug portion, duocarmycin SA (DMSA), is a cytotoxic small molecule which causes cell death by binding to the minor groove of DNA and alkylating the adenine. This product displays no obvious toxicity without a primary antibody and can be a quite efficient and economical alternative to pre-screening mouse monoclonal antibodies as ADC candidates.
Specific Inquiry
Specifications
- Antibody Overview
- anti-mouse IgG Fc specific polyclonal IgG antibody
- Antibody Isotype
- IgG
- Linker
- CL
- Linker Class/Description
- Class: Cleavable linkers
Description: Cleavable linkers rely on processes inside the cell to liberate the toxin, such as reduction in the cytoplasm, exposure to acidic conditions in the lysosome, or cleavage by specific proteases within the cell.
- Drug
- DMSA (duocarmycin SA)
- Drug Class/Description
- Class: Duocarmycins
Description: Duocarmycins belong to the minor-groove-binding DNA-alkylating agents (DNA MGBA). The natural duocarmycins are isolated from the culture broth of Streptmyces sp and a series of derivatives has also been synthesized
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "IgG Fc"
Select a product category from the dropdown menu below to view related products.
Please select product type
IgG Antibody Products
Fab Antibody Products
ScFv Antibody Products
Mouse Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-548 | Recombinant Anti-IgG Fc Antibody | ELISA, WB, Dot, FuncS | IgG |
| MHH-548 | Recombinant Human Anti-IgG Fc Antibody | IF, Neut, FuncS | IgG |
| PABZ-080 | Human Anti-IgG Fc Recombinant Antibody (PABZ-080) | WB, IF, FuncS | Human IgG |
| VS-0924-YC2 | Mouse Anti-Cat IgG Fc Recombinant Antibody (VS-0924-YC2) | ELISA | IgG |
| VS-0924-YC6 | Mouse Anti-Dog IgG Fc Recombinant Antibody (VS-0924-YC6) | ELISA | IgG |
Customer Reviews and Q&As
There are currently no Customer reviews or questions for ADC-1023-SMz. Click the button above to contact us or submit your feedback about this product.
Popular products with customers
Application: WB, IF, IP, Neut, FuncS, ELISA, FC
Application: IF, IP, Neut, FuncS, ELISA, FC, ICC
Application: ELISA, Neut, IF, IP, FC, FuncS
Application: WB, ELISA, FuncS, Inhib, PK, IP, SPR
Application: ELISA, WB, FC
Application: ELISA, FC, Neut, Inhib
For Research Use Only. Not For Clinical Use.
Send Inquiry
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
