Mouse Anti-ALPP (clone H17E2) scFv-Fc Chimera (CAT#: VS-0325-FY111)
The anti-ALPP scFv-Fc antibody targets ALPP (Alkaline Phosphatase, Placental), an enzyme involved in various physiological processes. It is designed with a scFv-Fc fusion to enhance targeting efficiency and functional versatility. This antibody is valuable for studying ALPP's role in cell biology and its potential as a therapeutic target.
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Subcellular Location and Protein Expression
Normal Tissue
Figure 1 IF staining of human cell line HeLa
(Immunofluorescent staining of human cell line HeLa shows localization to plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/38764/1046_F10_4_selected.jpg
(Immunofluorescent staining of human cell line HeLa shows localization to plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/38764/1046_F10_4_selected.jpg
Figure 2 IHC staining of human placenta
(Immunohistochemical staining of human placenta shows strong membranous and cytoplasmic positivity in trophoblastic cells.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/38765/98876_A_1_7_selected.jpg
(Immunohistochemical staining of human placenta shows strong membranous and cytoplasmic positivity in trophoblastic cells.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/38765/98876_A_1_7_selected.jpg
Figure 3 Placenta
(Trophoblastic cells
Staining:High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/38764/98884_A_1_7.jpg
(Trophoblastic cells
Staining:High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/38764/98884_A_1_7.jpg
Specifications
- Host Species
- Mouse
- Type
- Mouse IgG1, scFv-Fc
- Specificity
- Human ALPP
- Species Reactivity
- Human
- Clone
- H17E2
- Applications
- Immunohistochemistry, ELISA, Flow Cytometry
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- ELISA: 1:100-1:2000
Flow Cytometry: 10 ug/mL
Immunohistochemistry: 1:10-1:500
Immunohistochemistry-Frozen: 1:10-1:500
Target
- Alternative Names
- Alkaline Phosphatase, Placental; Alkaline Phosphatase Regan Isozyme; Placental Alkaline Phosphatase 1; EC 3.1.3.1; PLAP-1; PLAP; Alkaline Phosphatase, Placental (Regan Isozyme)
- Gene ID
- 250
- UniProt ID
- P05187
- Long Name
- Alkaline Phosphatase, Placental
- Cellular Localization
- Cell membrane
- Function
- ALPP, or alkaline phosphatase, placental, is an isoenzyme of alkaline phosphatase found primarily in the placenta during pregnancy. Its main function is to catalyze the hydrolysis of phosphate monoesters at an alkaline pH. While its exact physiological role is not fully understood, it is believed to contribute to placental function and fetal development. ALPP is also used as a tumor marker, particularly in the diagnosis of certain cancers, such as testicular cancer.
Recommended Products
Secondary Antibody
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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Antibody Magnetic Beads
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NAB-146-sdAb | Recombinant Anti-Human ALPP VHH Single Domain Antibody | FUNC, FA, IP, ChiP | Llama VHH |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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