Mouse Anti-CALCA (clone CA11) scFv-Fc Chimera (CAT#: VS-0425-FY71)
This scFv-Fc fusion targets CALCA (Calcitonin gene-related peptide), a neuropeptide involved in vasodilation. It has potential applications in pain management and migraine therapy by modulating neurovascular pathways.
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Custom Production
We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.
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RNA Expression
Figure 1 RNA cell line category: Not detected
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000110680-CALCA
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000110680-CALCA
Figure 1 RNA cell line category: Not detected
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000110680-CALCA
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000110680-CALCA
Specifications
- Immunogen
- Human CGRP as an immunogen.
- Host Species
- Mouse
- Type
- Mouse IgG1, scFv-Fc
- Specificity
- Human CALCA
- Species Reactivity
- Human
- Clone
- CA11
- Applications
- ELISA
- Related Disease
- Allergic dermatitis; psoriasis; encephalitis: brain trauma; epilepsy; neurodegenerative disease; skin disease including pruritis, neurogenic cutaneous redness skin rosaceousness and erythema; inflammatory bowel disease
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- ELISA: 0.1 μg/mL
The optimal dilution concentration is determined by the experiment.
Target
- Alternative Names
- Calcitonin Related Polypeptide Alpha; Calcitonin Gene-Related Peptide I; Alpha-Type CGRP; Calcitonin 1; Calcitonin; CGRP-I; CALC1; Calcitonin/Calcitonin-Related Polypeptide, Alpha
- Gene ID
- 796
- UniProt ID
- P01258
- Long Name
- Calcitonin Related Polypeptide Alpha
- Sequence Similarities
- Belongs to the calcitonin family.
- Cellular Localization
- Secreted
- Post Translation Modifications
- Glycosylation at Thr105 and Thr109
Modification sites at PhosphoSitePlus
Glycosylation from GlyGen 3 sites, 1 O-linked glycan (3 sites)
- Protein Refseq
- XP_054225903.1; XP_054225904.1; NP_001029124.1; NP_001029125.1; NP_001365878.1
- Function
- CGRP1/CALCA is a peptide hormone that induces vasodilation mediated by the CALCRL-RAMP1 receptor complex.
Dilates a variety of vessels including the coronary, cerebral and systemic vasculature.
Its abundance in the CNS also points toward a neurotransmitter or neuromodulator role.
It also elevates platelet cAMP.
CGRP1 can also bind and activate CALCR-RAMP1 (AMYR1) receptor complex.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Fab Antibody Products
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IgG Antibody Products
ScFv Antibody Products
IgM Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| DrMAB-1020 | Recombinant Mouse Anti-Human CALCA Antibody Fab Fragment | ELISA | Fab |
| HPAB-0188-FY-F(E) | Human Anti-CALCA Recombinant Antibody; Fab Fragment (HPAB-0188-FY-F(E)) | ELISA, Inhib | Humanized Fab |
| HPAB-0238-FY-F(E) | Human Anti-CALCA Recombinant Antibody; Fab Fragment (HPAB-0238-FY-F(E)) | ELISA | Humanized Fab |
| HPAB-0186-WJ-F(E) | Mouse Anti-CALCA Recombinant Antibody (clone 7D5); Fab Fragment | ELISA. IHC | Mouse Fab |
| HPAB-M0296-YC-F(E) | Mouse Anti-CALCA Recombinant Antibody (clone CA11); Fab Fragment | ELISA | Mouse Fab |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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