Mouse Anti-IL12A (clone 5F2) scFv-Fc Chimera
CAT#: VS-0425-FY121
Anti-IL12A scFv-Fc is a recombinant antibody targeting the p35 subunit (IL12A) of Interleukin-12 (IL-12), a cytokine that drives Th1 immune responses. The scFv provides specific binding to IL12A, while the Fc region offers stability and potential for dimerization. This format is being developed to block IL-12 signaling, aiming to modulate Th1-mediated inflammation in autoimmune diseases and other conditions.
Gene Expression
Normal Tissue
Figure 1 Cerebral cortex
Neuronal cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1886/7336_B_8_5.jpg
Normal Tissue
Figure 2 Colon
Glandular cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Peripheral nerve/ganglion
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1886/7336_A_8_3.jpg
Normal Tissue
Figure 3 Kidney
Cells in tubules
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1886/7336_A_7_5.jpg
Normal Tissue
Figure 4 Testis
Leydig cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1886/7336_A_4_6.jpg
RNA Expression
Figure 5 RNA cell line category: Cell line enhanced (BJ hTERT+ SV40 Large T+ RasG12V, HDLM-2, SK-BR-3)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000168811-IL12A
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Specifications
- Immunogen
- Recombinant human IL-12 protein.
- Host Species
- Mouse
- Type
- Mouse IgG1, scFv-Fc
- Specificity
- Human IL12A
- Species Reactivity
- Human, Rhesus monkey
- Clone
- 5F2
- Applications
- Inhibition
- Related Disease
- Autoimmune disease
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- The optimal dilution concentration is determined by the experiment.
Target
- Alternative Names
- Interleukin 12A
- Gene ID
- 3592
- UniProt ID
- P29459
- Long Name
- Interleukin 12A
- Sequence Similarities
- Belongs to the IL-6 superfamily.
- Cellular Localization
- Secreted
- Post Translation Modifications
- Glycosylation at Asn93 and Asn107
Modification sites at PhosphoSitePlus
Glycosylation from GlyGen 2 sites, 1 N-linked glycan (1 site)
- Protein Refseq
- NP_000873.2; NP_001341511.1; NP_001341512.1; NP_001384921.1
- Function
- Heterodimerizes with IL12B to form the IL-12 cytokine or with EBI3/IL27B to form the IL-35 cytokine.
IL-12 is primarily produced by professional antigen-presenting cells (APCs) such as B-cells and dendritic cells (DCs) as well as macrophages and granulocytes and regulates T-cell and natural killer-cell responses, induces the production of interferon-gamma (IFN-gamma), favors the differentiation of T-helper 1 (Th1) cells and is an important link between innate resistance and adaptive immunity.
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Related Diseases
Inflammatory Bowel Diseases
Allograft Rejection
Autoimmune Thyroid Disease
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| NAB-1394-VHH | Recombinant Anti-Human IL12A VHH Single Domain Antibody | IHC, IP, FC, Neut, FUNC | Llama VHH |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-0251MC | Rabbit Anti-IL12 Antibody | WB, ELISA | |
| HPAB-1549-FY | Mouse Anti-IL12A Recombinant Antibody (HPAB-1549-FY) | Neut, WB, IHC | Mouse IgG |
| HPAB-1550-FY | Mouse Anti-IL12A Recombinant Antibody (HPAB-1550-FY) | WB, IHC | Mouse IgG |
| HPAB-1551-FY | Mouse Anti-IL12A Recombinant Antibody (HPAB-1551-FY) | WB, ELISA | Mouse IgG |
| VS3-WK1525 | Rat Anti-IL12A Recombinant Antibody (clone 4AC17.8) | IF, FC | Rat IgG2a, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| BRD-0280MZ | Chicken Anti-Interleukin-12A Polyclonal IgY | WB | Chicken antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1160CQ | Rat Anti-Il12a Recombinant Antibody (clone C18.2) | ELISA, FuncS, Neut | Rat IgG2a, κ |
| NEUT-1165CQ | Mouse Anti-IL12A Recombinant Antibody (clone CBL732) | Neut, WB | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1788 | Rabbit Anti-IL12A Recombinant Antibody (clone DS1788AB) | WB, IP | Rabbit IgG |
| MOR-4607 | Rabbit Anti-IL12A Recombinant Antibody (clone TH120DS) | WB | Rabbit IgG |
| MOR-4608 | Rabbit Anti-IL12A Recombinant Antibody (clone TH121DS) | WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-1549-FY-F(E) | Mouse Anti-IL12A Recombinant Antibody; Fab Fragment (HPAB-1549-FY-F(E)) | WB, ELISA | Mouse Fab |
| HPAB-1550-FY-F(E) | Mouse Anti-IL12A Recombinant Antibody; Fab Fragment (HPAB-1550-FY-F(E)) | WB, ELISA | Mouse Fab |
| HPAB-1551-FY-F(E) | Mouse Anti-IL12A Recombinant Antibody; Fab Fragment (HPAB-1551-FY-F(E)) | WB, ELISA | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-1549-FY-S(P) | Mouse Anti-IL12A Recombinant Antibody; scFv Fragment (HPAB-1549-FY-S(P)) | WB, ELISA | Mouse scFv |
| HPAB-1550-FY-S(P) | Mouse Anti-IL12A Recombinant Antibody; scFv Fragment (HPAB-1550-FY-S(P)) | WB, ELISA | Mouse scFv |
| HPAB-1551-FY-S(P) | Mouse Anti-IL12A Recombinant Antibody; scFv Fragment (HPAB-1551-FY-S(P)) | WB, ELISA | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY3481 | Anti-IL12A Immunohistochemistry Kit | IHC | |
| VS-0525-XY3482 | Anti-Mouse Il12a Immunohistochemistry Kit | IHC |
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