Mouse Anti-NPPB scFv-Fc Chimera (VS-0325-FY189)
CAT#: VS-0325-FY189
The anti-NT-proBNP scFv-Fc antibody targets NT-proBNP (N-terminal pro-B-type natriuretic peptide), a biomarker for heart failure and cardiovascular diseases. This antibody provides specific detection and targeting of NT-proBNP, with potential applications in diagnostic research and therapeutic development related to cardiovascular conditions.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line CACO-2
Immunofluorescent staining of human cell line CACO-2 shows localization to cytosol & vesicles.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/77324/1928_E11_1_selected.jpg
RNA Expression
Figure 2 RNA cell line category: Cell line enhanced (BEWO, CACO-2, SuSa)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000120937-NPPB
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Specifications
- Immunogen
- The NT-proBNP epitope prediction design, 76 amino acid molecule, the synthesis of the two linear epitope conjugated KLH immunization, the antibody Abl immune found 5-27 amino acid linear epitope obtained, Ab5 amino acids 61-76 of an antibody immune linear epitope obtained.
- Host Species
- Mouse
- Type
- Mouse IgG1, scFv-Fc
- Specificity
- Human NPPB
- Species Reactivity
- Human
- Applications
- ELISA
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Target
- Alternative Names
- Natriuretic Peptide B; Natriuretic Peptide Precursor B; Gamma-Brain Natriuretic Peptide; Brain Type Natriuretic Peptide; Natriuretic Peptides B; Natriuretic Protein; BNP; ProBNP
- Gene ID
- 4879
- UniProt ID
- P16860
- Long Name
- Natriuretic Peptide B
- Sequence Similarities
- Belongs to the natriuretic peptide family.
- Cellular Localization
- Secreted
- Post Translation Modifications
- The precursor molecule is proteolytically cleaved by the endoproteases FURIN or CORIN at Arg-102 to produce brain natriuretic peptide 32 and NT-proBNP.
Glycosylation at Thr62, Ser63, Ser70, Thr74, Ser79, Thr84, and Thr97
Modification sites at PhosphoSitePlus
Glycosylation from GlyGen 8 sites, 1 O-linked glycan (4 sites)
- Protein Refseq
- NP_002512.1
- Function
- Human NPPB (Natriuretic peptide B) is a cardiac hormone secreted by the ventricles in response to increased ventricular volume and pressure. It plays a crucial role in regulating fluid balance and blood pressure, and is used as a biomarker for heart failure.
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Secondary Antibody
- CAT
- Product Name
See other products for "NPPB"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-0403ZL | Mouse Anti-Human NPPB Antibody | ELISA, Immunoassay, WB | |
| MOB-0033MZ | Recombinant Mouse Anti-Human NPPB Antibody (clone 14H13) | IA, WB | Mouse antibody |
| HPAB-0476-YJ | Human Anti-NPPB Recombinant Antibody (clone 3C1) | ELISA, DB, Neut | Human IgG |
| VS3-XY1178 | Mouse Anti-NPPB Recombinant Antibody (clone 3A6F7C7) | ELISA, IHC | Mouse IgG1 |
| VS3-XY1179 | Mouse Anti-NPPB Recombinant Antibody (clone 8D5B4C11) | ELISA, IHC | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABX-017 | Recombinant Mouse Anti-BNP Antibody (106.3) | FuncS | IgG |
| PABX-017-S (P) | Recombinant Mouse Anti-BNP Antibody scFv Fragment (106.3) | WB, ELISA, IF, FuncS | scFv |
| PABX-017-F (E) | Recombinant Mouse Anti-BNP Antibody Fab Fragment (106.3) | WB, ELISA, IF, FuncS | Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-2481 | Hi-Affi™ Recombinant Rabbit Anti-NPPB Monoclonal Antibody (DS2481AB) | WB | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0476-YJ-S(P) | Human Anti-NPPB Recombinant Antibody (clone 3C1); scFv Fragment | ELISA, DB, Neut | Human scFv |
| HPAB-0477-YJ-S(P) | Mouse Anti-NPPB Recombinant Antibody (clone 8C7E11); scFv Fragment | ELISA, LF | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0476-YJ-F(E) | Human Anti-NPPB Recombinant Antibody (clone 3C1); Fab Fragment | ELISA, DB, Neut | Human Fab |
| HPAB-0477-YJ-F(E) | Mouse Anti-NPPB Recombinant Antibody (clone 8C7E11); Fab Fragment | ELISA, LF | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY4925 | Anti-NPPB Immunohistochemistry Kit | IHC | |
| VS-0525-XY4926 | Anti-Mouse NPPB Immunohistochemistry Kit | IHC |
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