Recombinant Mouse Anti-ACKR3 Antibody (clone 5E6C8) (CAT#: VS3-FY432)

• Host Species
• Mouse

• Type
• Mouse IgG1

• Specificity
• ACKR3

• Clone
• 5E6C8

• Applications
• Enzyme-linked Immunosorbent Assay, Immunohistochemistry, Immunocytochemistry, Flow Cytometry

• Conjugate
• Unconjugated

• Purity
• >95%

• Storage
• Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

• Application Notes
• This antibody has been reported for use in Enzyme-linked Immunosorbent Assay, Immunohistochemistry, Immunocytochemistry, Flow Cytometry.

• Alternative Names
• Atypical Chemokine Receptor 3; Chemokine Orphan Receptor 1; G-Protein Coupled Receptor RDC1 Homolog; Chemokine (C-X-C Motif) Receptor 7; C-X-C Chemokine Receptor Type 7; G-Protein Coupled Receptor 159; CMKOR1; CXC-R7

• Gene ID
• 57007

• UniProt ID
• P25106

• Sequence Similarities
• Belongs to the G-protein coupled receptor 1 family. Atypical chemokine receptor subfamily.

• Cellular Localization
• Cell membrane, Endosome, Membrane

• Post Translation Modifications
• The Ser/Thr residues in the C-terminal cytoplasmic tail may be phosphorylated.
  Ubiquitinated at the Lys residues in its C-terminal cytoplasmic tail and is essential for correct trafficking from and to the cell membrane. Deubiquitinated by CXCL12-stimulation in a reversible manner.

• Protein Refseq
• NP_064707.1

• Function
• Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Acts as a receptor for chemokines CXCL11 and CXCL12/SDF1 (PubMed:16107333, PubMed:19255243, PubMed:19380869, PubMed:20161793, PubMed:22300987).
  Chemokine binding leads to ligand internalization and activation of MAPK signaling pathway (PubMed:16940167, PubMed:18653785, PubMed:20018651).
  Required for regulation of CXCR4 protein levels in migrating interneurons, thereby adapting their chemokine responsiveness (PubMed:16940167, PubMed:18653785).
  In glioma cells, transduces signals via MEK/ERK pathway, mediating resistance to apoptosis. Promotes cell growth and survival (PubMed:16940167, PubMed:20388803).
  Not involved in cell migration, adhesion or proliferation of normal hematopoietic progenitors but activated by CXCL11 in malignant hemapoietic cells, leading to phosphorylation of ERK1/2 (MAPK3/MAPK1) and enhanced cell adhesion and migration (PubMed:17804806, PubMed:18653785, PubMed:19641136, PubMed:20887389).
  Plays a regulatory role in CXCR4-mediated activation of cell surface integrins by CXCL12 (PubMed:18653785).
  Required for heart valve development (PubMed:17804806).
  Regulates axon guidance in the oculomotor system through the regulation of CXCL12 levels (PubMed:31211835).
  (Microbial infection) Acts as coreceptor with CXCR4 for a restricted number of HIV isolates.

Secondary Antibody

• 2ND-047CQ
• Goat Anti-Mouse IgG1 Antibody, R-PE

• 2RD-A1460-YJ
• Goat Anti-Mouse IgG1 Secondary antibody

• 2RD-A1562-YJ
• Rabbit Anti-Mouse IgG1 Secondary antibody (Clone RM106)

Isotype Control

• MOB-065CQ
• Mouse IgG1 Isotype Control Antibody

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