Recombinant Anti-ACVR2B Vesicular Antibody, EV Displayed (VS-0425-YC316)
CAT#: VS-0425-YC316
The Recombinant Anti-ACVR2B Vesicular Antibody, EV Displayed (VS-0425-YC316) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to ACVR2B-expressed cells or tissues. The ACVR2B is a receptor for activins playing roles in growth factor signaling, with type II receptors showing higher ligand affinity.
Gene Expression
Subcellular Location and Protein Expression
Figure 1 IF staining of cell line A-431
Immunofluorescent staining of cell line A-431 shows localization to cytosol.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/115/672_E2_1_blue_red_green.jpg
Subcellular Location and Protein Expression
Figure 2 IF staining of cell line U-2 OS
Immunofluorescent staining of cell line U-2 OS shows localization to cytosol.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/115/663_E2_1_blue_red_green.jpg
Subcellular Location and Protein Expression
Figure 3 IF staining of cell line U-251 MG
Immunofluorescent staining of cell line U-251 MG shows localization to cytosol.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/115/646_E2_1_blue_red_green.jpg
Normal Tissue
Figure 4 Colon
Endocrine cells
Staining:High
Intensity: Strong
Enterocytes
Staining:Medium
Intensity: Strong
Quantity: <25%
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/3804/10580_A_9_3.jpg
Normal Tissue
Figure 5 Kidney
Cells in tubules
Staining:Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/3804/10580_A_9_5.jpg
Normal Tissue
Figure 6 Testis
Pachytene spermatocytes
Staining:High
Intensity: Strong
Quantity: 75%-25% Spermatogonia cells
Staining:Medium
Intensity: Strong
Quantity: <25%
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/3804/10580_A_4_6.jpg
Normal Tissue
Figure 7 Placenta
Decidual cells
Staining:Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
Trophoblastic cells
Staining:Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/3804/10580_A_2_7.jpg
Normal Tissue
Figure 8 Lymph node
Germinal center cells
Staining:High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining:Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/3804/10580_A_8_8.jpg
❮
❯
Recombinant Antibody
- Application
- ELISA, FC, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- ACVR2B
- Host Animal
- Human
- Antibody Isotype
- IgG
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- z domain
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Binding Affinity
- Kd = 0.85 µg/mL
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- Activin A receptor type 2B
- Molecular Function
- Kinase, Receptor, Serine/threonine-protein kinase, Transferase
- Introduction
- Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases. This gene encodes activin A type IIB receptor, which displays a 3- to 4-fold higher affinity for the ligand than activin A type II receptor.
- Alternative Names
- ActR-IIB
- Gene ID
- 93
- UniProt ID
- Q13705
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Datasheet
MSDS
COA
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| CAT | Product Name | Application | Type |
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| HPAB-0038-FY-S(P) | Human Anti-ACVR2B Recombinant Antibody; scFv Fragment (HPAB-0038-FY-S(P)) | ELISA | Human scFv |
| HPAB-0575-WJ-S(P) | Human Anti-ACVR2B Recombinant Antibody; scFv Fragment (HPAB-0575-WJ-S(P)) | ELISA | Human scFv |
| HPAB-0576-WJ-S(P) | Human Anti-ACVR2B Recombinant Antibody; scFv Fragment (HPAB-0576-WJ-S(P)) | ELISA | Human scFv |
| HPAB-0577-WJ-S(P) | Human Anti-ACVR2B Recombinant Antibody; scFv Fragment (HPAB-0577-WJ-S(P)) | ELISA | Human scFv |
| HPAB-0578-WJ-S(P) | Human Anti-ACVR2B Recombinant Antibody; scFv Fragment (HPAB-0578-WJ-S(P)) | ELISA | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-N0010-YC | Human Anti-ACVR2B Recombinant Antibody (HPAB-N0010-YC) | FC | Human IgG |
| HPAB-0575-WJ | Human Anti-ACVR2B Recombinant Antibody (HPAB-0575-WJ) | ELISA | Human IgG |
| HPAB-0576-WJ | Human Anti-ACVR2B Recombinant Antibody (HPAB-0576-WJ) | ELISA | Human IgG |
| VS3-FY1964 | Rabbit Anti-ACVR2B Recombinant Antibody (clone R01-2I1) | WB | Rabbit IgG |
| VS-0824-YJ24 | Human Anti-ACVR2B Recombinant Antibody (clone CBA103) | IA | Human IgG1 kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-N0010-YC-F(E) | Human Anti-ACVR2B Recombinant Antibody Fab Fragment (HPAB-N0010-YC-F(E)) | FC | Human Fab |
| HPAB-0575-WJ-F(E) | Human Anti-ACVR2B Recombinant Antibody; Fab Fragment (HPAB-0575-WJ-F(E)) | ELISA | Human Fab |
| HPAB-0576-WJ-F(E) | Human Anti-ACVR2B Recombinant Antibody; Fab Fragment (HPAB-0576-WJ-F(E)) | ELISA | Human Fab |
| HPAB-0577-WJ-F(E) | Human Anti-ACVR2B Recombinant Antibody; Fab Fragment (HPAB-0577-WJ-F(E)) | ELISA | Human Fab |
| HPAB-0578-WJ-F(E) | Human Anti-ACVR2B Recombinant Antibody; Fab Fragment (HPAB-0578-WJ-F(E)) | ELISA | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-FY31 | Human Anti-ACVR2B scFv-Fc Chimera (VS-0425-FY31) | IA | Human IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY140 | Anti-ACVR2B Immunohistochemistry Kit | IHC |
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