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    Human Anti-ACVR2B Recombinant Antibody Fab Fragment (HPAB-N0010-YC-F(E)) (CAT#: HPAB-N0010-YC-F(E))

    A multi-round selection procedure was used to select for human antibodies that bind ActRII with high affinity and compete with activin A for binding human ActRII. The clone was determined to bind across two stretches of sites on AcRIIB, with binding epitopes mapped to amino acids 9 through to 17 (NANWELERT) and amino acids 49 through to 63 (VKKGCWLDD).

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    • Size:

    • Conjugation:

    • Endotoxin:

    • Purity:

    Custom Production

    We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.

    Sequences:
    Isotype :
    Purity :
    Endotoxin :
    Quantity :
    Conjugation :
    Fc Engineering :
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    Other Requirements:
    We require custom production
    • Gene Expression
    • Datasheet
    • MSDS
    • COA
    Subcellular Location and Protein Expression
    Figure 1 IF staining of cell line A-431
    Figure 1 IF staining of cell line A-431
    (Immunofluorescent staining of cell line A-431 shows localization to cytosol.)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/115/672_E2_1_blue_red_green.jpg
    Figure 2 IF staining of cell line U-2 OS
    Figure 2 IF staining of cell line U-2 OS
    (Immunofluorescent staining of cell line U-2 OS shows localization to cytosol.)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/115/663_E2_1_blue_red_green.jpg
    Figure 3 IF staining of cell line U-251 MG
    Figure 3 IF staining of cell line U-251 MG
    (Immunofluorescent staining of cell line U-251 MG shows localization to cytosol.)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/115/646_E2_1_blue_red_green.jpg
    Normal Tissue
    Figure 4 Colon
    Figure 4 Colon
    (Endocrine cells
    Staining:High
    Intensity: Strong
    Enterocytes
    Staining:Medium
    Intensity: Strong
    Quantity: <25%)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/3804/10580_A_9_3.jpg
    Figure 5 Kidney
    Figure 5 Kidney
    (Cells in tubules
    Staining:Medium
    Intensity: Strong
    Quantity: <25%
    Location: Cytoplasmic/membranous)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/3804/10580_A_9_5.jpg
    Figure 6 Testis
    Figure 6 Testis
    (Pachytene spermatocytes
    Staining:High
    Intensity: Strong
    Quantity: 75%-25% Spermatogonia cells
    Staining:Medium
    Intensity: Strong
    Quantity: <25%)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/3804/10580_A_4_6.jpg
    Figure 7 Placenta
    Figure 7 Placenta
    (Decidual cells
    Staining:Medium
    Intensity: Strong
    Quantity: <25%
    Location: Cytoplasmic/membranous
    Trophoblastic cells
    Staining:Medium
    Intensity: Strong
    Quantity: <25%
    Location: Cytoplasmic/membranous)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/3804/10580_A_2_7.jpg
    Figure 8 Lymph node
    Figure 8 Lymph node
    (Germinal center cells
    Staining:High
    Intensity: Strong
    Quantity: 75%-25%
    Location: Cytoplasmic/membranous
    Non-germinal center cells
    Staining:Medium
    Intensity: Strong
    Quantity: <25%
    Location: Cytoplasmic/membranous)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/3804/10580_A_8_8.jpg

    Specifications

    • Host Species
    • Human
    • Type
    • Human Fab
    • Specificity
    • Human ACVR2B
    • Species Reactivity
    • Human
    • Applications
    • FC

    Product Property

    • Purity
    • >95% as determined by SDS-PAGE and HPLC analysis
    • Buffer
    • PBS
    • Preservative
    • No preservatives
    • Storage
    • Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

    Target

    • Alternative Names
    • Activin A Receptor Type 2B; Activin A Receptor, Type IIB; EC 2.7.11.30; ActR-IIB; Activin Receptor Type IIB; Activin Receptor Type-2B; EC 2.7.11; ACTRIIB; HTX4

    Product Notes

    This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

    • Increased sensitivity
    • Confirmed specificity
    • High repeatability
    • Excellent batch-to-batch consistency
    • Sustainable supply
    • Animal-free production

    See more details about Hi-Affi™ recombinant antibody benefits.

    Downloads

    Download resources about recombinant antibody development and antibody engineering to boost your research.

    See other products for "ACVR2B"

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    CAT Product Name Application Type
    NAB-50-sdAb Recombinant Anti-Human ACVR2B VHH Single Domain Antibody WB, IP, ChiP, Neut, ELISA Llama VHH

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    For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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