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    Human Anti-ACVR2B scFv-Fc Chimera (VS-0425-FY31) (CAT#: VS-0425-FY31)

    The anti-ACVR2B scFv-Fc antibody is a monoclonal antibody with high affinity that specifically binds to the human AcRIIB protein. AcRIIB is a receptor for activins A and B, growth factors that play important roles in various biological processes, including cell proliferation, differentiation, and apoptosis. The antibody binds specifically to two regions of AcRIIB through its single-chain variable fragment (scFv) domain, and the Fc fragment endows it with the ability to interact with immune effector molecules such as Fc receptors and the complement system. This high-affinity binding characteristic makes it a potential therapeutic tool for treating diseases associated with abnormal activation of the activin signaling pathway, such as certain types of cancer and fibrotic diseases. Additionally, the antibody can be used to study the role of the activin signaling pathway in diseases and as a potential therapeutic target.

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    • Purity:

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    • Fc Engineering:

    • Modalities:

    Custom Production

    We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.

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    We require custom production
    • Gene Expression
    • Datasheet
    • MSDS
    • COA
    Subcellular Location and Protein Expression
    Figure 1 IF staining of cell line A-431
    Figure 1 IF staining of cell line A-431
    (Immunofluorescent staining of cell line A-431 shows localization to cytosol.)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/115/672_E2_1_blue_red_green.jpg
    Figure 2 IF staining of cell line U-2 OS
    Figure 2 IF staining of cell line U-2 OS
    (Immunofluorescent staining of cell line U-2 OS shows localization to cytosol.)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/115/663_E2_1_blue_red_green.jpg
    Figure 3 IF staining of cell line U-251 MG
    Figure 3 IF staining of cell line U-251 MG
    (Immunofluorescent staining of cell line U-251 MG shows localization to cytosol.)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/115/646_E2_1_blue_red_green.jpg
    Normal Tissue
    Figure 4 Colon
    Figure 4 Colon
    (Endocrine cells
    Staining:High
    Intensity: Strong
    Enterocytes
    Staining:Medium
    Intensity: Strong
    Quantity: <25%)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/3804/10580_A_9_3.jpg
    Figure 5 Kidney
    Figure 5 Kidney
    (Cells in tubules
    Staining:Medium
    Intensity: Strong
    Quantity: <25%
    Location: Cytoplasmic/membranous)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/3804/10580_A_9_5.jpg
    Figure 6 Testis
    Figure 6 Testis
    (Pachytene spermatocytes
    Staining:High
    Intensity: Strong
    Quantity: 75%-25% Spermatogonia cells
    Staining:Medium
    Intensity: Strong
    Quantity: <25%)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/3804/10580_A_4_6.jpg
    Figure 7 Placenta
    Figure 7 Placenta
    (Decidual cells
    Staining:Medium
    Intensity: Strong
    Quantity: <25%
    Location: Cytoplasmic/membranous
    Trophoblastic cells
    Staining:Medium
    Intensity: Strong
    Quantity: <25%
    Location: Cytoplasmic/membranous)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/3804/10580_A_2_7.jpg
    Figure 8 Lymph node
    Figure 8 Lymph node
    (Germinal center cells
    Staining:High
    Intensity: Strong
    Quantity: 75%-25%
    Location: Cytoplasmic/membranous
    Non-germinal center cells
    Staining:Medium
    Intensity: Strong
    Quantity: <25%
    Location: Cytoplasmic/membranous)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/3804/10580_A_8_8.jpg

    Specifications

    • Host Species
    • Human
    • Type
    • Human IgG1, scFv-Fc
    • Specificity
    • Human ACVR2B
    • Species Reactivity
    • Human
    • Applications
    • Immunoassay
    • Related Disease
    • Musculoskeletal; Connective Tissue disease (Miscellaneous)

    Product Property

    • Purity
    • >95% as determined by SDS-PAGE
    • Concentration
    • Please refer to the vial label for the specific concentration.
    • Storage
    • Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
    • Shipping
    • Ice packs

    Applications

    • Application Notes
    • The optimal dilution concentration is determined by the experiment.

    Target

    • Alternative Names
    • Activin A Receptor Type 2B; Activin A Receptor, Type IIB; EC 2.7.11.30; ActR-IIB; Activin Receptor Type IIB; Activin Receptor Type-2B; EC 2.7.11; ACTRIIB; HTX4
    • Long Name
    • Activin A Receptor Type 2B
    • Sequence Similarities
    • Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
    • Cellular Localization
    • Cell membrane, Membrane
    • Post Translation Modifications
    • Phosphorylated.
      Constitutive phosphorylation is in part catalyzed by its own kinase activity.
      Glycosylation at Asn42 and Asn65
      Modification sites at PhosphoSitePlus
      Glycosylation from GlyGen 2 sites
    • Function
    • Activin is also thought to have a paracrine or autocrine role in follicular development in the ovary. Within the receptor complex, the type-2 receptors act as a primary activin receptors (binds activin-A/INHBA, activin-B/INHBB as well as inhibin-A/INHA-INHBA). The type-1 receptors like ACVR1B act as downstream transducers of activin signals. Activin binds to type-2 receptor at the plasma membrane and activates its serine-threonine kinase. The activated receptor type-2 then phosphorylates and activates the type-1 receptor.

    Product Notes

    This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

    • Increased sensitivity
    • Confirmed specificity
    • High repeatability
    • Excellent batch-to-batch consistency
    • Sustainable supply
    • Animal-free production

    See more details about Hi-Affi™ recombinant antibody benefits.

    Downloads

    Download resources about recombinant antibody development and antibody engineering to boost your research.

    See other products for "ACVR2B"

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    CAT Product Name Application Type
    NAB-50-sdAb Recombinant Anti-Human ACVR2B VHH Single Domain Antibody WB, IP, ChiP, Neut, ELISA Llama VHH

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