Human Anti-ACVR2B scFv-Fc Chimera (VS-0425-FY31)
CAT#: VS-0425-FY31
The anti-ACVR2B scFv-Fc antibody is a monoclonal antibody with high affinity that specifically binds to the human AcRIIB protein. AcRIIB is a receptor for activins A and B, growth factors that play important roles in various biological processes, including cell proliferation, differentiation, and apoptosis. The antibody binds specifically to two regions of AcRIIB through its single-chain variable fragment (scFv) domain, and the Fc fragment endows it with the ability to interact with immune effector molecules such as Fc receptors and the complement system. This high-affinity binding characteristic makes it a potential therapeutic tool for treating diseases associated with abnormal activation of the activin signaling pathway, such as certain types of cancer and fibrotic diseases. Additionally, the antibody can be used to study the role of the activin signaling pathway in diseases and as a potential therapeutic target.
Gene Expression
Subcellular Location and Protein Expression
Figure 1 IF staining of cell line A-431
Immunofluorescent staining of cell line A-431 shows localization to cytosol.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/115/672_E2_1_blue_red_green.jpg
Subcellular Location and Protein Expression
Figure 2 IF staining of cell line U-2 OS
Immunofluorescent staining of cell line U-2 OS shows localization to cytosol.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/115/663_E2_1_blue_red_green.jpg
Subcellular Location and Protein Expression
Figure 3 IF staining of cell line U-251 MG
Immunofluorescent staining of cell line U-251 MG shows localization to cytosol.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/115/646_E2_1_blue_red_green.jpg
Normal Tissue
Figure 4 Colon
Endocrine cells
Staining:High
Intensity: Strong
Enterocytes
Staining:Medium
Intensity: Strong
Quantity: <25%
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/3804/10580_A_9_3.jpg
Normal Tissue
Figure 5 Kidney
Cells in tubules
Staining:Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/3804/10580_A_9_5.jpg
Normal Tissue
Figure 6 Testis
Pachytene spermatocytes
Staining:High
Intensity: Strong
Quantity: 75%-25% Spermatogonia cells
Staining:Medium
Intensity: Strong
Quantity: <25%
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/3804/10580_A_4_6.jpg
Normal Tissue
Figure 7 Placenta
Decidual cells
Staining:Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
Trophoblastic cells
Staining:Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/3804/10580_A_2_7.jpg
Normal Tissue
Figure 8 Lymph node
Germinal center cells
Staining:High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining:Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/3804/10580_A_8_8.jpg
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Specifications
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Specificity
- Human ACVR2B
- Species Reactivity
- Human
- Applications
- Immunoassay
- Related Disease
- Musculoskeletal; Connective Tissue disease (Miscellaneous)
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- The optimal dilution concentration is determined by the experiment.
Target
- Alternative Names
- Activin A Receptor Type 2B; Activin A Receptor, Type IIB; EC 2.7.11.30; ActR-IIB; Activin Receptor Type IIB; Activin Receptor Type-2B; EC 2.7.11; ACTRIIB; HTX4
- Gene ID
- 93
- UniProt ID
- Q13705
- Long Name
- Activin A Receptor Type 2B
- Sequence Similarities
- Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
- Cellular Localization
- Cell membrane, Membrane
- Post Translation Modifications
- Phosphorylated.
Constitutive phosphorylation is in part catalyzed by its own kinase activity.
Glycosylation at Asn42 and Asn65
Modification sites at PhosphoSitePlus
Glycosylation from GlyGen 2 sites
- Protein Refseq
- XP_005265640.1; XP_016863003.1; XP_016863004.1; XP_016863005.1; NP_001097.2
- Function
- Activin is also thought to have a paracrine or autocrine role in follicular development in the ovary. Within the receptor complex, the type-2 receptors act as a primary activin receptors (binds activin-A/INHBA, activin-B/INHBB as well as inhibin-A/INHA-INHBA). The type-1 receptors like ACVR1B act as downstream transducers of activin signals. Activin binds to type-2 receptor at the plasma membrane and activates its serine-threonine kinase. The activated receptor type-2 then phosphorylates and activates the type-1 receptor.
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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| CAT | Product Name | Application | Type |
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| HPAB-0038-FY | Human Anti-ACVR2B Recombinant Antibody (HPAB-0038-FY) | ELISA, FC, Inhib, FuncS | Human IgG2 |
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| CAT | Product Name | Application | Type |
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| HPAB-0038-FY-S(P) | Human Anti-ACVR2B Recombinant Antibody; scFv Fragment (HPAB-0038-FY-S(P)) | ELISA | Human scFv |
| HPAB-0575-WJ-S(P) | Human Anti-ACVR2B Recombinant Antibody; scFv Fragment (HPAB-0575-WJ-S(P)) | ELISA | Human scFv |
| HPAB-0576-WJ-S(P) | Human Anti-ACVR2B Recombinant Antibody; scFv Fragment (HPAB-0576-WJ-S(P)) | ELISA | Human scFv |
| HPAB-0577-WJ-S(P) | Human Anti-ACVR2B Recombinant Antibody; scFv Fragment (HPAB-0577-WJ-S(P)) | ELISA | Human scFv |
| HPAB-0578-WJ-S(P) | Human Anti-ACVR2B Recombinant Antibody; scFv Fragment (HPAB-0578-WJ-S(P)) | ELISA | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-N0010-YC-F(E) | Human Anti-ACVR2B Recombinant Antibody Fab Fragment (HPAB-N0010-YC-F(E)) | FC | Human Fab |
| HPAB-0575-WJ-F(E) | Human Anti-ACVR2B Recombinant Antibody; Fab Fragment (HPAB-0575-WJ-F(E)) | ELISA | Human Fab |
| HPAB-0576-WJ-F(E) | Human Anti-ACVR2B Recombinant Antibody; Fab Fragment (HPAB-0576-WJ-F(E)) | ELISA | Human Fab |
| HPAB-0577-WJ-F(E) | Human Anti-ACVR2B Recombinant Antibody; Fab Fragment (HPAB-0577-WJ-F(E)) | ELISA | Human Fab |
| HPAB-0578-WJ-F(E) | Human Anti-ACVR2B Recombinant Antibody; Fab Fragment (HPAB-0578-WJ-F(E)) | ELISA | Human Fab |
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| VS-0425-YC316 | Recombinant Anti-ACVR2B Vesicular Antibody, EV Displayed (VS-0425-YC316) | ELISA, FC, Cell-uptake |
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| VS-0525-XY140 | Anti-ACVR2B Immunohistochemistry Kit | IHC |
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