Recombinant Anti-AGER Vesicular Antibody, EV Displayed (VS-0425-YC640)

CAT#: VS-0425-YC640

The Recombinant Anti-AGER Vesicular Antibody, EV Displayed (VS-0425-YC640) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to AGER-expressed cells or tissues. AGER is a glycosylation end product receptor, interacting with various molecules linked to diseases like diabetes and Alzheimer's.

Gene Expression
Figure 1 IF staining of human cell line MCF7 Figure 2 Lung Figure 3 RNA cell line category: Cell line enhanced (HEK93, JURKAT, RPTEC TERT1, U-266/70, U-266/84)

Recombinant Antibody

  • Application
  • ELISA, FC, Neut, Cell-uptake
  • Product Type
  • Ab-Fc-EVs
  • Antibody Quantification (Ab/EV)
  • ~100 Ab/EV
  • Target
  • AGER
  • Host Animal
  • Mouse
  • Antibody Isotype
  • IgG
  • Species Reactivity
  • Human, Mouse
  • Expression Cell
  • Mammalian cell

Engineered EVs

  • EV-sorting domain
  • CD63
  • Fc-binding domain
  • Protein A
  • EV Size
  • 30~150 nm
  • Producing Cell
  • HEK293F
  • Isolation Method
  • Gradient centrifugation
  • Purification
  • qEV size exclusion chromatography
  • Concentration
  • 1 x 10¹⁰
  • Size
  • 1 mL
  • Buffer
  • PBS
  • Storage
  • Store at -80°C for 12 months

Target

  • Full Name
  • Advanced glycosylation end-product specific receptor
  • Biological Process
  • Inflammatory response
  • Cellular Localization
  • Plasma membrane, Cell Junctions, Nucleoli fibrillar center
  • Introduction
  • The advanced glycosylation end product (AGE) receptor encoded by this gene is a member of the immunoglobulin superfamily of cell surface receptors. It is a multiligand receptor, and besides AGE, interacts with other molecules implicated in homeostasis, development, and inflammation, and certain diseases, such as diabetes and Alzheimer's disease. Many alternatively spliced transcript variants encoding different isoforms, as well as non-protein-coding variants, have been described for this gene (PMID:18089847). [provided by RefSeq, May 2011]
  • Alternative Names
  • RAGE, SCARJ1, sRAGE
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