Recombinant monoclonal antibody specifically binds to RAGE and neutralizes RAGE-associated activities. This antibody can be potentially used for treating RAGE-related disease.
Figure 1 Radioactive equivalent concentrations and total radioactivity, as percentage of administered dose (% dose) of [125I]anti-RAGE Ab in serum, lung and spleen of RAGE-/- and wild-type (129S5) mice following a single 5 mg/kg IV dose.
Serum and tissue RE concentrations were monitored by gamma-counting up to ∼5 mo (132 days) in RAGE-/- (open circles) and wild-type (wt) 129S5 (open triangle) mice. The insert in shows serum RE concentrations up to day 9 post-dose. Data show mean ± SD values, with n = 6 per time point. Individual animal concentration values that were less than the limit of quantitation were treated as zero for calculations of the mean and the standard deviation.
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For research use only. Not intended for any clinical use.