Recombinant monoclonal antibody specifically binds to RAGE and neutralizes RAGE-associated activities. This antibody can be potentially used for treating RAGE-related disease.
Figure 1 3B4 has a high affinity to mouse RAGE while the control M4 does not bind mouse RAGE.
SPR sensorgrams of A. anti-RAGE scFv (3B4) and B. control scFv (M4) using the Langmuir 1:1 binding model.
Figure 2 Confocal microscopic images of RAGE expressing Panc02 cells.
Live cells were incubated with 3B4-Cy5 and M4-Cy5. After fixation, the nucleus was counterstained with DAPI (Scale bar = 10 μm).
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