Recombinant Anti-ALK Vesicular Antibody, EV Displayed (VS-0425-YC625)
CAT#: VS-0425-YC625
The Recombinant Anti-ALK Vesicular Antibody, EV Displayed (VS-0425-YC625) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to ALK-expressed cells or tissues. ALK is a tyrosine kinase part of the insulin receptor superfamily, implicated in brain development and various tumors like lymphoma and neuroblastoma.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line RH-30
Immunofluorescent staining of human cell line RH-30 shows localization to plasma membrane.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/10694/1416_A5_3_selected.jpg
Normal Tissue
Figure 2 Cerebral cortex
Neuronal cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous nuclear Neuropil Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/10694/26100_B_8_5.jpg
Normal Tissue
Figure 3 Cerebellum
Cells in molecular layer Staining: Low Intensity: Moderate Quantity: <25% Location: Nuclear Purkinje cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/10694/26100_B_7_8.jpg
Normal Tissue
Figure 4 Colon
Glandular cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Peripheral nerve/ganglion Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/10694/26075_A_7_3.jpg
Normal Tissue
Figure 5 Testis
Cells in seminiferous ducts Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/10694/26075_A_6_6.jpg
RNA Expression
Figure 6 RNA cell line category: Cell line enriched (SH-SY5Y)
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000171094-ALK
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Recombinant Antibody
- Application
- ELISA, FC, Stim, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- ALK
- Host Animal
- Mouse
- Antibody Isotype
- IgG
- Species Reactivity
- Human
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- Protein A
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- ALK receptor tyrosine kinase
- Molecular Function
- Kinase, Receptor, Transferase, Tyrosine-protein kinase
- Cellular Localization
- Plasma membrane
- Introduction
- This gene encodes a receptor tyrosine kinase, which belongs to the insulin receptor superfamily. This protein comprises an extracellular domain, an hydrophobic stretch corresponding to a single pass transmembrane region, and an intracellular kinase domain. It plays an important role in the development of the brain and exerts its effects on specific neurons in the nervous system. This gene has been found to be rearranged, mutated, or amplified in a series of tumours including anaplastic large cell lymphomas, neuroblastoma, and non-small cell lung cancer. The chromosomal rearrangements are the most common genetic alterations in this gene, which result in creation of multiple fusion genes in tumourigenesis, including ALK (chromosome 2)/EML4 (chromosome 2), ALK/RANBP2 (chromosome 2), ALK/ATIC (chromosome 2), ALK/TFG (chromosome 3), ALK/NPM1 (chromosome 5), ALK/SQSTM1 (chromosome 5), ALK/KIF5B (chromosome 10), ALK/CLTC (chromosome 17), ALK/TPM4 (chromosome 19), and ALK/MSN (chromosome X).[provided by RefSeq, Jan 2011]
- Alternative Names
- ALK1, CD246
- Gene ID
- 238
- UniProt ID
- Q9UM73
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Related Diseases
EGFR Tyrosine Kinase Inhibitor Resistance
Downloadable Resources
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Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "ALK"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1446z | Mouse Anti-ALK Recombinant Antibody (clone 26D9) | WB, FC, ICC, IF | Mouse IgG1, κ |
| HPAB-0138-YC | Mouse Anti-ALK Recombinant Antibody (HPAB-0138-YC) | ELISA, FC, WB, Inhib | Mouse IgG |
| HPAB-0139-YC | Mouse Anti-ALK Recombinant Antibody (HPAB-0139-YC) | ELISA, WB, FC, Agonist | Mouse IgG |
| HPAB-0140-YC | Mouse Anti-ALK Recombinant Antibody (HPAB-0140-YC) | ELISA, FC, WB | Mouse IgG |
| HPAB-0141-YC | Mouse Anti-ALK Recombinant Antibody (HPAB-0141-YC) | ELISA, FC, RIA, Inhib | Mouse IgG, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0147 | Hi-Affi™ Rabbit Anti-ALK Recombinant Antibody (clone DS147AB) | IHC-P | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0138-YC-S(P) | Mouse Anti-ALK Recombinant Antibody; scFv Fragment (HPAB-0138-YC-S(P)) | ELISA, FC, WB | Mouse scFv |
| HPAB-0139-YC-S(P) | Mouse Anti-ALK Recombinant Antibody; scFv Fragment (HPAB-0139-YC-S(P)) | ELISA, FC, WB | Mouse scFv |
| HPAB-0140-YC-S(P) | Mouse Anti-ALK Recombinant Antibody; scFv Fragment (HPAB-0140-YC-S(P)) | ELISA, FC, WB | Mouse scFv |
| HPAB-0141-YC-S(P) | Mouse Anti-ALK Recombinant Antibody; scFv Fragment (HPAB-0141-YC-S(P)) | ELISA, FC, RIA | Mouse scFv |
| HPAB-0143-YC-S(P) | Mouse Anti-ALK Recombinant Antibody (clone D10); scFv Fragment | ELISA, FC, Stim | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0138-YC-F(E) | Mouse Anti-ALK Recombinant Antibody; Fab Fragment (HPAB-0138-YC-F(E)) | ELISA, FC, WB | Mouse Fab |
| HPAB-0139-YC-F(E) | Mouse Anti-ALK Recombinant Antibody; Fab Fragment (HPAB-0139-YC-F(E)) | ELISA, FC, WB | Mouse Fab |
| HPAB-0140-YC-F(E) | Mouse Anti-ALK Recombinant Antibody; Fab Fragment (HPAB-0140-YC-F(E)) | ELISA, FC, WB | Mouse Fab |
| HPAB-0141-YC-F(E) | Mouse Anti-ALK Recombinant Antibody; Fab Fragment (HPAB-0141-YC-F(E)) | ELISA, FC, RIA | Mouse Fab |
| HPAB-0143-YC-F(E) | Mouse Anti-ALK Recombinant Antibody (clone D10); Fab Fragment | ELISA, FC, Stim | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NS-004CN | Human Anti-ALK Recombinant Antibody (clone ESBA521) | ELISA, WB, FuncS | Human IgG |
| NS-004CN-F(E) | Human Anti-ALK Recombinant Antibody (clone ESBA521); Fab Fragment | ELISA, WB | Human Fab |
| NS-004CN-S(P) | Human Anti-ALK Recombinant Antibody (clone ESBA521); scFv Fragment | ELISA, WB | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-YF574 | A*02:01/Human Mutant anaplastic lymphoma kinase (SLAMLDLLHV) MHC Pentamer | FCM |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY319 | Anti-ALK Immunohistochemistry Kit | IHC |
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