Recombinant Anti-CD1D Vesicular Antibody, EV Displayed (VS-0425-YC231)

Name: Recombinant Anti-CD1D Vesicular Antibody, EV Displayed (VS-0425-YC231)
SKU: VS-0425-YC231
Rating: 5 (1 reviews)

CAT#: VS-0425-YC231

The Recombinant Anti-CD1D Vesicular Antibody, EV Displayed (VS-0425-YC231) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to CD1D-expressed cells or tissues. The CD1D is a molecule involved in immune response pathways, related to diseases like Autoimmune Disease. It engages in receptor and cell adhesion molecule binding.

Gene Expression

Subcellular Location and Protein Expression Figure 1 IF staining of human cell line HEK 293

Immunofluorescent staining of human cell line HEK 293 shows localization to endoplasmic reticulum.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/72662/1466_F8_4_selected.jpg

Subcellular Location and Protein Expression Figure 2 IF staining of human cell line HaCaT

Immunofluorescent staining of human cell line HaCaT shows localization to endoplasmic reticulum.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/72662/1576_B7_1_blue_red_green.jpg

Subcellular Location and Protein Expression Figure 3 IF staining of human cell line U-2 OS

Immunofluorescent staining of human cell line U-2 OS shows localization to endoplasmic reticulum.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/72662/1521_F8_2_blue_red_green.jpg

Normal Tissue Figure 4 Cerebral cortex

Neuronal cells
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/16107/35972_B_7_5.jpg

Normal Tissue Figure 5 Colon

Mucosal lymphoid cells
Staining:Medium
Intensity: Strong
Quantity: <25%

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/16107/35972_A_7_3.jpg

Normal Tissue Figure 6 Testis

Leydig cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/16107/35972_A_6_6.jpg

Normal Tissue Figure 7 Lymph node

Non-germinal center cells
Staining:High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/16107/35972_A_9_8.jpg

Normal Tissue Figure 8 Spleen

Cells in white pulp
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/16107/35972_B_8_4.jpg

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Recombinant Antibody

Application
ELISA, FC, Inhib, Cell-uptake

Product Type
Ab-Fc-EVs

Antibody Quantification (Ab/EV)
~100 Ab/EV

Target
CD1D

Host Animal
Human

Antibody Isotype
IgG

Species Reactivity
Cynomolgus

Expression Cell
Mammalian cell

Engineered EVs

EV-sorting domain
CD63

Fc-binding domain
z domain

EV Size
30~150 nm

Producing Cell
HEK293F

Isolation Method
Gradient centrifugation

Purification
qEV size exclusion chromatography

Binding Affinity
Kd = 0.85 µg/mL

Concentration
1 x 10¹⁰

Size
1 mL

Buffer
PBS

Storage
Store at -80°C for 12 months

Target

Full Name
CD1d molecule

Biological Process
Immunity, Innate immunity

Cellular Localization
Endoplasmic reticulum

Introduction
CD1D (CD1d Molecule) is a Protein Coding gene. Diseases associated with CD1D include Mycobacterium Malmoense and Autoimmune Disease. Among its related pathways are Innate Immune System and Amoebiasis. Gene Ontology (GO) annotations related to this gene include receptor activity and cell adhesion molecule binding. An important paralog of this gene is CD1E.

Gene ID
102142140

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Datasheet

Datasheet - VS-0425-YC231.pdf

MSDS

MSDS - VS-0425-YC231.pdf

COA

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