Recombinant Anti-CD48 Vesicular Antibody, EV Displayed (VS-0425-YC685) (CAT#: VS-0425-YC685)
The Recombinant Anti-CD48 Vesicular Antibody, EV Displayed (VS-0425-YC685) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to CD48-expressed cells or tissues. CD48 enables receptor ligand activity, participating in mast cell activation, and is part of a protein complex with a human ortholog.
Specific Inquiry
Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line U-2 OS
(Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoli fibrillar center, plasma membrane & cytosol.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/55146/1674_C10_33_selected.jpg
(Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoli fibrillar center, plasma membrane & cytosol.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/55146/1674_C10_33_selected.jpg
Figure 2 High expression in tonsil.
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2497/ihc_selected.jpg
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2497/ihc_selected.jpg
Figure 3 Low expression in cerebral cortex.
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2497/6580_B_7_5_val_selected.jpg
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2497/6580_B_7_5_val_selected.jpg
Figure 4 Lymph node
(Germinal center cells Staining: Not detected Intensity: Weak Quantity: <25% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2497/6580_A_9_8.jpg
(Germinal center cells Staining: Not detected Intensity: Weak Quantity: <25% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2497/6580_A_9_8.jpg
Figure 5 Tonsil
(Non-germinal center cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2497/6580_A_4_8.jpg
(Non-germinal center cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2497/6580_A_4_8.jpg
Figure 6 RNA cell line category: Cell line enhanced (Daudi, HMC-1, U-266/70, U-266/84)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000117091-CD48
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000117091-CD48
Recombinant Antibody
- Application
- Block, ELISA, FC, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- CD48
- Host Animal
- Mouse
- Antibody Isotype
- IgG
- Species Reactivity
- Rat
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- Protein A
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- CD48 molecule
- Cellular Localization
- Plasma membrane, Nucleoli fibrillar center, Cytosol
- Introduction
- Predicted to enable receptor ligand activity. Involved in mast cell activation. Part of protein-containing complex. Orthologous to human CD48 (CD48 molecule).
- Alternative Names
- SLAMF2
- Gene ID
- 245962
- UniProt ID
- P10252
Downloads
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-132CL | Anti-Human CD48 Recombinant Antibody | ELISA, Inhib, FuncS | Antibody |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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