Mouse Anti-CD48 Recombinant Antibody Hexamer (VS-0924-YC119), CDC Enhanced (CAT#: VS-0924-YC119)
The product is a Hexameric Anti-CD48 Mouse Antibody engineered for enhanced complement-dependent cytotoxicity (CDC) activity. This IgG1 antibody targeting human CD48 features hexamerization-enhancing mutations, promoting hexamer formation to optimize C1q binding and boost CDC efficacy.
Specific Inquiry
Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line U-2 OS
(Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoli fibrillar center, plasma membrane & cytosol.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/55146/1674_C10_33_selected.jpg
(Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoli fibrillar center, plasma membrane & cytosol.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/55146/1674_C10_33_selected.jpg
Figure 2 High expression in tonsil.
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2497/ihc_selected.jpg
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2497/ihc_selected.jpg
Figure 3 Low expression in cerebral cortex.
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2497/6580_B_7_5_val_selected.jpg
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2497/6580_B_7_5_val_selected.jpg
Figure 4 Lymph node
(Germinal center cells Staining: Not detected Intensity: Weak Quantity: <25% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2497/6580_A_9_8.jpg
(Germinal center cells Staining: Not detected Intensity: Weak Quantity: <25% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2497/6580_A_9_8.jpg
Figure 5 Tonsil
(Non-germinal center cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2497/6580_A_4_8.jpg
(Non-germinal center cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2497/6580_A_4_8.jpg
Figure 6 RNA cell line category: Cell line enhanced (Daudi, HMC-1, U-266/70, U-266/84)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000117091-CD48
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000117091-CD48
Specifications
- Immunogen
- Human CD48 transfected cells
- Host Species
- Mouse
- Type
- Antibody hexamer
- Specificity
- Human CD48
- Species Reactivity
- Human
- Molecule Class
- ~ 900 kDa
- Applications
- ELISA, Cyt, CDC
- Conjugate
- None
- Related Disease
- Multiple myeloma
Product Property
- Clonality
- Monoclonal
- Purification
- Protein G purified
- Purity
- >95% determined as SDS-PAGE and SEC-HPLC
- Aggregation
- <5%
- Buffer
- PBS, pH 7.4
- Preservative
- No preservatives
- Storage
- Store at 4°C short term (1-2 weeks). Store at -20°C long term (12 months). Avoid repeated freeze/thaw cycles.
Target
- Alternative Names
- CD48; BCM1; BLAST; hCD48; mCD48; BLAST1; SLAMF2; MEM-102
- Gene ID
- 962
- UniProt ID
- P09326
- Long Name
- CD48 Molecule
- Cellular Localization
- Cell membrane; Lipid-anchor, GPI-anchor
- Post Translation Modifications
- Glycosylation at Asn40, Asn44, Asn104, Asn162, Asn189, and Asn206 ( NX_P09326 [NX_P09326-1] )
Downloads
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-132CL | Anti-Human CD48 Recombinant Antibody | ELISA, Inhib, FuncS | Antibody |
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For Research Use Only. Not For Clinical Use.
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