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    Recombinant Anti-FCGR3A Vesicular Antibody, EV Displayed (VS-0425-YC21)

    CAT#: VS-0425-YC21

    The Recombinant Anti-FCGR3A Vesicular Antibody, EV Displayed (VS-0425-YC21) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to FCGR3A-expressed cells or tissues. The FCGR3A is a receptor for the Fc portion of immunoglobulin G, participating in antigen-antibody complex clearance and antibody-dependent responses. Mutations are linked to susceptibility to viral infections and systemic lupus erythematosus.

    Gene Expression
    ❮
    Figure 1 Cerebral cortex Figure 2 Lung Figure 3 Lymph node Figure 4 RNA cell line category: Not detected
    ❯

    Recombinant Antibody

    • Application
    • ELISA, FC, Cell-uptake
    • Product Type
    • Ab-Fc-EVs
    • Antibody Quantification (Ab/EV)
    • ~100 Ab/EV
    • Target
    • FCGR3A
    • Host Animal
    • Human
    • Antibody Isotype
    • IgG
    • Species Reactivity
    • Human
    • Expression Cell
    • Mammalian cell

    Engineered EVs

    • EV-sorting domain
    • CD63
    • Fc-binding domain
    • z domain
    • EV Size
    • 30~150 nm
    • Producing Cell
    • HEK293F
    • Isolation Method
    • Gradient centrifugation
    • Purification
    • qEV size exclusion chromatography
    • Binding Affinity
    • Kd = 0.85 µg/mL
    • Concentration
    • 1 x 10¹⁰
    • Size
    • 1 mL
    • Buffer
    • PBS
    • Storage
    • Store at -80°C for 12 months

    Target

    • Full Name
    • Fc gamma receptor IIIa
    • Biological Process
    • Immunity
    • Molecular Function
    • IgG-binding protein, Receptor
    • Introduction
    • This gene encodes a receptor for the Fc portion of immunoglobulin G, and it is involved in the removal of antigen-antibody complexes from the circulation, as well as other other antibody-dependent responses. This gene (FCGR3A) is highly similar to another nearby gene (FCGR3B) located on chromosome 1. The receptor encoded by this gene is expressed on natural killer (NK) cells as an integral membrane glycoprotein anchored through a transmembrane peptide, whereas FCGR3B is expressed on polymorphonuclear neutrophils (PMN) where the receptor is anchored through a phosphatidylinositol (PI) linkage. Mutations in this gene have been linked to susceptibility to recurrent viral infections, susceptibility to systemic lupus erythematosus, and alloimmune neonatal neutropenia.
    • Alternative Names
    • CD16, CD16a, FCG3, FcgammaRIIIa, FCGR3, FcGRIIIA
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    Datasheet

    Datasheet - VS-0425-YC21.pdf

    MSDS

    MSDS - VS-0425-YC21.pdf

    COA

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