Human Anti-FCGR3A (clone hu3G8) scFv-Fc Chimera (CAT#: VS-0325-FY213)

The anti-FCGR3A scFv-Fc antibody targets FCGR3A (CD16), a receptor involved in antibody-dependent cell-mediated cytotoxicity (ADCC). This antibody is designed to study the role of FCGR3A in immune responses and cancer immunotherapy. The scFv-Fc format enhances its stability and half-life, making it suitable for both in vitro and in vivo studies related to immunotherapy and cell signaling.

Specific Inquiry
  • Size:
  • Conjugation:
  • Endotoxin:
  • Purity:
  • Formats:
  • Isotype Switching:
  • Fc Engineering:
  • Modalities:
  • Gene Expression
  • Datasheet
  • MSDS
  • COA
Normal Tissue
RNA Expression

Specifications

  • Host Species
  • Human
  • Type
  • Human IgG1, scFv-Fc
  • Specificity
  • Human FCGR3A
  • Species Reactivity
  • Human
  • Clone
  • hu3G8
  • Applications
  • ELISA

Product Property

  • Purity
  • >95% as determined by SDS-PAGE
  • Concentration
  • Please refer to the vial label for the specific concentration.
  • Storage
  • Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
  • Shipping
  • Ice packs

Target

  • Alternative Names
  • Fc Fragment Of IgG Receptor IIIa; Fc Fragment Of IgG, Low Affinity IIIa, Receptor (CD16a); Fc Gamma Receptor IIIa; IgG Fc Receptor III-2; Fc-Gamma RIII-Alpha; Fc-Gamma RIIIa; Fc-Gamma RIII; CD16a Antigen; FCRIIIA; FCR-10; FCRIII; FCGR3; CD16A; IGFR3; FCG3
  • Long Name
  • Fc Fragment Of IgG Receptor IIIa
  • Cellular Localization
  • Cell membrane; Secreted
  • Post Translation Modifications
  • Glycosylated.
    Contains high mannose- and complex-type oligosaccharides.
    Glycosylation at Asn-180 is mandatory for high affinity binding to the Fc and for discrimination between fucosylated and afucosylated IgG glycoforms.
    Undergoes rapid ectodomain shedding upon NK cell stimulation.
    The soluble form is produced by a proteolytic cleavage mediated by ADAM17.
    Repeated stimulation causes receptor shedding, a mechanism that allows for increased NK cell motility and detachment from opsonized target cells while avoiding activation-induced NK cell apoptosis.
    Phosphorylated at RSSTR motif by PKC.
    The relevant physiological PKCs might be PRKCI, PRKCG, PRKCE, PRKCH and PRKCQ.
    Glycosylation at Asn56, Asn63, Asn92, Asn180, and Asn187
    Modification sites at PhosphoSitePlus
    Glycosylation from GlyConnect FCG3A_HUMAN (3000)
    Glycosylation from GlyGen 6 sites
  • Function
  • Binds antigen-IgG complexes generated upon infection and triggers NK cell-dependent cytokine production and degranulation to limit viral load and propagation.
    Involved in the generation of memory-like adaptive NK cells capable to produce high amounts of IFNG and to efficiently eliminate virus-infected cells via ADCC (PubMed:25786175, 24412922).
    Regulates NK cell survival and proliferation, in particular by preventing NK cell progenitor apoptosis (PubMed:9916693, 29967280).
    Fc-binding subunit that associates with CD247 and/or FCER1G adapters to form functional signaling complexes.

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Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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