Recombinant Rabbit Anti-GRIA1 (phospho Ser845) Antibody (clone R03-7G4)
CAT#: VS3-FY614
This product is a recombinant rabbit antibody that recognizes GRIA1. This antibody has been reported for use in Western Blot. The clone R03-7G4 is specific for human, rat GRIA1. The antigen is a synthetic phosphopeptide corresponding to residues surrounding ser845 of human ampa receptor 1 (glua1).
Tested Data
Gene Expression
WB
Figure 1. Recombinant Rabbit Anti-GRIA1 (phospho Ser845) Antibody (clone R03-7G4) in WB.
Western Blot analysis of phosphoglutamate receptor 1 (AMPA subtype) (Ser845) in C6 lysates using Phosphoglutamate receptor 1 (AMPA subtype) (Ser845) Antibody.
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Normal Tissue
Figure 1 Hippocampal formation
High expression
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/35202/ihc_selected.jpg
Normal Tissue
Figure 2 Cerebral cortex
Neuronal cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/35202/135520_B_7_5.jpg
Normal Tissue
Figure 3 Hippocampus
Neuronal cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/35202/135520_B_7_6.jpg
Normal Tissue
Figure 4 Kidney
Cells in tubules Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/35202/135520_A_8_5.jpg
Normal Tissue
Figure 5 Lymph node
Non-germinal center cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/35202/135520_A_8_8.jpg
RNA Expression
Figure 6 RNA cell line category: Cell line enhanced (AF22, ASC diff, BJ, BJ hTERT+, LHCN-M2, U-266/70)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000155511-GRIA1
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Specifications
- Immunogen
- A synthetic phosphopeptide corresponding to residues surrounding Ser845 of human AMPA receptor 1 (GluA1).
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human, Rat GRIA1
- Species Reactivity
- Human, Rat
- Clone
- R03-7G4
- Applications
- Western Blot
- Conjugate
- Unconjugated
- MW
- Calculated MW: 102 kDa; Observed MW: 102 kDa
Product Property
- Purification
- Affinity Purified
- Purity
- >95% as determined by SDS-PAGE
- Buffer
- 50 mM Tris-Glycine, pH 7.4, 0.15 M NaCl, 40% glycerol, 0.05% BSA
- Preservative
- 0.01% Sodium azide
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- Western Blot: 1/500-1/1000
Target
- Alternative Names
- Glutamate Ionotropic Receptor AMPA Type Subunit 1; Glutamate Receptor, Ionotropic, AMPA 1; AMPA-Selective Glutamate Receptor 1; GluR-K1; GluR-1; GluR-A; GLUR1; GLUH1
- Gene ID
- 2890
- UniProt ID
- P42261
- Sequence Similarities
- Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIA1 subfamily.
- Cellular Localization
- Cell membrane, Cell projection, Endoplasmic reticulum, Endosome, Membrane, Postsynaptic cell membrane, Synapse
- Post Translation Modifications
- Palmitoylated. Depalmitoylated upon glutamate stimulation. Cys-603 palmitoylation leads to Golgi retention and decreased cell surface expression. In contrast, Cys-829 palmitoylation does not affect cell surface expression but regulates stimulation-dependent endocytosis (By similarity).
Phosphorylated at Ser-645. Phosphorylated at Ser-710 by PKC. Phosphorylated at Ser-849 by PKC, PKA and CAMK2. Phosphorylated at Ser-863 by PKC, PKA and PRKG2 (By similarity).
Phosphorylation of Ser-863 is reduced by induction of long-term depression and increased by induction of long-term potentiation (By similarity).
- Protein Refseq
- NP_000818.2; NP_001107655.1; NP_001244948.1
- Function
- Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Secondary Antibody
- CAT
- Product Name
Isotype Control
- CAT
- Product Name
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| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
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