Recombinant Anti-MUC16 Vesicular Antibody, EV Displayed (VS-0425-YC337)
CAT#: VS-0425-YC337
The Recombinant Anti-MUC16 Vesicular Antibody, EV Displayed (VS-0425-YC337) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to MUC16-expressed cells or tissues. The MUC16 is a mucin protein involved in forming mucous barriers and acts as a cancer marker with high expression.
Gene Expression
Normal Tissue
Figure 1 Cervix
Glandular cells
Staining:
High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/
membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/65600/166228_B_7_3.jpg
RNA Expression
Figure 2 RNA cell line category: Group enriched (A-431, HeLa)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000181143-MUC16
❮
❯
Recombinant Antibody
- Application
- ELISA, FC, Neut, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- MUC16
- Host Animal
- Mouse
- Antibody Isotype
- IgG
- Species Reactivity
- Human
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- Protein A
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- Mucin 16, cell surface associated
- Introduction
- This gene encodes a protein that is a member of the mucin family. Mucins are high molecular weight, O-glycosylated proteins that play an important role in forming a protective mucous barrier, and are found on the apical surfaces of the epithelia. The encoded protein is a membrane-tethered mucin that contains an extracellular domain at its amino terminus, a large tandem repeat domain, and a transmembrane domain with a short cytoplasmic domain. The amino terminus is highly glycosylated, while the repeat region contains 156 amino acid repeats unit that are rich in serines, threonines, and prolines. Interspersed within the repeats are Sea urchin sperm protein Enterokinase and Agrin (SEA) modules, leucine-rich repeats and ankyrin (ANK) repeats. These regions together form the ectodomain, and there is a potential cleavage site found near an SEA module close to the transmembrane domain. This protein is thought to play a role in forming a barrier, protecting epithelial cells from pathogens. Products of this gene have been used as a marker for different cancers, with higher expression levels associated with poorer outcomes. [provided by RefSeq, May 2017]
- Alternative Names
- CA-125, CA125, FLJ14303
- Gene ID
- 94025
- UniProt ID
- Q8WXI7
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Datasheet
MSDS
COA
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| FAMAB-0044YC | Human Anti-MUC16 Recombinant Antibody (clone ch196-14) | FuncS | Chimeric (mouse/human) IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-H63 | Humanized Anti-MUC16 Recombinant V-kappa Antibody (TAB-H63) | IF, IP, Neut, FuncS, ELISA, FC, WB | Humanized IgG1, κ |
| TAB-0339CL | Human Anti-MUC16 Recombinant Antibody (TAB-0339CL) | DB, WB, IP, ELISA, FC, CDC | Humanized Antibody |
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| TAB-1399CL | Human Anti-MUC16 Recombinant Antibody (TAB-1399CL) | FuncS | Humanized IgG |
| TAB-0339CL-S(P) | Human Anti-MUC16 Recombinant Antibody; scFv Fragment (TAB-0339CL-S(P)) | DB, WB, IP, ELISA, FC | Humanized scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
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| TAB-1402CL | Anti-Human MUC16 Recombinant Antibody (VK-8) | IF, FC | |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-1398CL | Human Anti-MUC16 Recombinant Antibody (TAB-1398CL) | FuncS | Chimeric (mouse/human) IgG |
| TAB-1400CL | Human Anti-MUC16 Recombinant Antibody (TAB-1400CL) | FuncS | Chimeric (mouse/human) IgG |
| TAB-1398CL-S(P) | Mouse Anti-MUC16 Recombinant Antibody; scFv Fragment (TAB-1398CL-S(P)) | FuncS | Mouse scFv |
| TAB-1400CL-S(P) | Mouse Anti-MUC16 Recombinant Antibody; scFv Fragment (TAB-1400CL-S(P)) | FuncS | Mouse scFv |
| TAB-1398CL-F(E) | Human Anti-MUC16 Recombinant Antibody; Fab Fragment (TAB-1398CL-F(E)) | FuncS | Chimeric (mouse/human) Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0310-YC-S(P) | Mouse Anti-MUC16 Recombinant Antibody; scFv Fragment (HPAB-0310-YC-S(P)) | ELISA, FC, IHC, FuncS | Mouse scFv |
| FAMAB-0043-YC-S(P) | Mouse Anti-MUC16 Recombinant Antibody (clone 196-14); scFv Fragment | FuncS | Mouse scFv |
| FAMAB-0044-YC-S(P) | Mouse Anti-MUC16 Recombinant Antibody (clone ch196-14); scFv Fragment | FuncS | Mouse scFv |
| HPAB-1114LY-S(P) | Mouse Anti-MUC16 Recombinant Antibody; scFv Fragment (HPAB-1114LY-S(P)) | ELISA | Mouse scfv |
| HPAB-1115LY-S(P) | Mouse Anti-MUC16 Recombinant Antibody; scFv Fragment (HPAB-1115LY-S(P)) | ELISA | Mouse scfv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0310-YC-F(E) | Mouse Anti-MUC16 Recombinant Antibody; Fab Fragment (HPAB-0310-YC-F(E)) | ELISA, FC, IHC, FuncS | Mouse Fab |
| FAMAB-0043-YC-F(E) | Mouse Anti-MUC16 Recombinant Antibody (clone 196-14); Fab Fragment | FuncS | Mouse Fab |
| FAMAB-0044-YC-F(E) | Human Anti-MUC16 Recombinant Antibody (clone ch196-14); Fab Fragment | FuncS | Human Fab |
| HPAB-1114LY-F(E) | Mouse Anti-MUC16 Recombinant Antibody; Fab Fragment (HPAB-1114LY-F(E)) | ELISA | Mouse Fab |
| HPAB-1115LY-F(E) | Mouse Anti-MUC16 Recombinant Antibody; Fab Fragment (HPAB-1115LY-F(E)) | ELISA | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
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| CAT | Product Name | Application | Type |
|---|---|---|---|
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| CAT | Product Name | Application | Type |
|---|---|---|---|
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| CAT | Product Name | Application | Type |
|---|---|---|---|
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| CAT | Product Name | Application | Type |
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