Recombinant Anti-NECTIN4 Vesicular Antibody, EV Displayed (VS-0425-YC71)
CAT#: VS-0425-YC71
The Recombinant Anti-NECTIN4 Vesicular Antibody, EV Displayed (VS-0425-YC71) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to NECTIN4-expressed cells or tissues. The NECTIN4 is a protein involved in cell adhesion, linked to ectodermal dysplasia-syndactyly syndrome.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to plasma membrane.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/10775/1671_G1_2_selected.jpg
Normal Tissue
Figure 2 Skin 1
High expression in skin 1
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/10775/27075_B_9_1_val_selected.jpg
Normal Tissue
Figure 3 Colon
Glandular cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/10775/27075_A_9_3.jpg
Normal Tissue
Figure 4 Kidney
Cells in tubules Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/10775/27075_A_9_5.jpg
Normal Tissue
Figure 5 Testis
Leydig cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/10775/27075_A_6_6.jpg
Normal Tissue
Figure 6 Skin
Epidermal cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/10775/27075_B_5_8.jpg
RNA Expression
Figure 7 RNA cell line category: Cell line enhanced (BEWO, HaCaT, MCF7, OE19, SK-BR-3, T-47d)
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000143217-NECTIN4
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Recombinant Antibody
- Application
- ELISA, FC, Neut, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- NECTIN4
- Host Animal
- Human
- Antibody Isotype
- IgG
- Species Reactivity
- Human
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- z domain
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Binding Affinity
- Kd = 0.85 µg/mL
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- Nectin cell adhesion molecule 4
- Biological Process
- Cell adhesion, Host-virus interaction
- Molecular Function
- Host cell receptor for virus entry, Receptor
- Cellular Localization
- Plasma membrane
- Introduction
- This gene encodes a member of the nectin family. The encoded protein contains two immunoglobulin-like (Ig-like) C2-type domains and one Ig-like V-type domain. It is involved in cell adhesion through trans-homophilic and -heterophilic interactions. It is a single-pass type I membrane protein. The soluble form is produced by proteolytic cleavage at the cell surface by the metalloproteinase ADAM17/TACE. The secreted form is found in both breast tumor cell lines and breast tumor patients. Mutations in this gene are the cause of ectodermal dysplasia-syndactyly syndrome type 1, an autosomal recessive disorder. Alternatively spliced transcript variants have been found but the full-length nature of the variant has not been determined.[provided by RefSeq, Jan 2011]
- Alternative Names
- LNIR, nectin-4, PRR4, PVRL4
- Gene ID
- 81607
- UniProt ID
- Q96NY8
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Datasheet
MSDS
COA
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See other products for "NECTIN4"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-H25 | Human Anti-NECTIN4 Recombinant Antibody (TAB-H25) | ELISA, Neut, IF, IP, FC, FuncS | Human IgG1, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0034-DJB | Mouse Anti-NECTIN4 Recombinant Antibody (clone N41) | ELISA, IHC, FC | Mouse IgG |
| VS4-CJ51 | Recombinant Human Anti-NECTIN4 Antibody (clone 6D3) | ELISA | Human IgG1 |
| VS-0723-WK124 | Human Anti-NECTIN4 Recombinant Antibody (VS-0723-WK124) | FC | Chimeric (rabbit/human) IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0034-DJB-S(P) | Mouse Anti-NECTIN4 Recombinant Antibody (clone N41); scFv Fragment | ELISA, IHC, FC | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0034-DJB-F(E) | Mouse Anti-NECTIN4 Recombinant Antibody (clone N41); Fab Fragment | ELISA, IHC, FC | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-FY114 | Human Anti-NECTIN4 (clone Enfortumab) scFv-Fc Chimera | ELISA, Neut, IF, IP, FC | Human IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0825-YC265 | SmartAb™ Recombinant Anti-NECTIN4 pH-dependent Antibody (VS-0825-YC265) | ELISA, Neut, IF, IP, FC | Human IgG1 kappa |
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