Recombinant Rabbit Anti-NUDT5 Antibody (clone 10D2) (CAT#: VS4-CJ62)
This rabbit anti-NUDT5 antibody (clone 10D2) is a product that recognizes human NUDT5. The immunogen of this antibody is a synthesized peptide derived from human NUDT5. The mAb has been tested for use in ELISA, Western Blot (1:500-1:2000), Flow Cytometry (1:50-1:200).
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Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line U-2 OS
(Immunofluorescent staining of human cell line U-2 OS shows localization to vesicles.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/19827/if_selected.jpg
(Immunofluorescent staining of human cell line U-2 OS shows localization to vesicles.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/19827/if_selected.jpg
Figure 2 IHC staining of human liver
(Immunohistochemical staining of human liver shows moderate cytoplasmic positivity in hepatocytes.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/19827/ihc_selected.jpg
(Immunohistochemical staining of human liver shows moderate cytoplasmic positivity in hepatocytes.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/19827/ihc_selected.jpg
Figure 3 Liver
(Hepatocytes Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/19827/48121_A_7_4.jpg
(Hepatocytes Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/19827/48121_A_7_4.jpg
Figure 4 Kidney
(Cells in tubules Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/19827/48121_A_7_5.jpg
(Cells in tubules Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/19827/48121_A_7_5.jpg
Figure 5 Testis
(Elongated or late spermatids Staining: Medium Intensity: Moderate Quantity: 75%-25%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/19827/48121_A_4_6.jpg
(Elongated or late spermatids Staining: Medium Intensity: Moderate Quantity: 75%-25%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/19827/48121_A_4_6.jpg
Figure 6 RNA cell line category: Low cell line specificity
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000165609-NUDT5
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000165609-NUDT5
Specifications
- Immunogen
- A synthesized peptide derived from human NUDT5
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human NUDT5
- Species Reactivity
- Human
- Clone
- 10D2
- Applications
- ELISA, WB, FC
- Conjugate
- Unconjugated
Product Property
- Purification
- Affinity chromatography
- Purity
- >95% as determined by SDS-PAGE
- Format
- Liquid
- Buffer
- 50% Glycerol, 150 mM NaCl, PBS, pH 7.4.
- Preservative
- 0.02% Sodium Azide
- Storage
- Store at -20°C or -80°C upon receipt. Avoid repeated freeze.
Applications
- Application Notes
- This antibody has been tested for use in ELISA, Western Blot (1:500-1:2000), Flow Cytometry (1:50-1:200).
Target
- Alternative Names
- YSA1; YSA1H; YSAH1; Hnudt5
- Gene ID
- 11164
- UniProt ID
- Q9UKK9
- Long Name
- Nudix hydrolase 5
- Sequence Similarities
- Belongs to the Nudix hydrolase family.
- Cellular Localization
- Nucleus
- Post Translation Modifications
- Phosphorylation at Thr-45 is required for homodimer stability; dephosphorylation results in destabilization of the homodimer. Dephosphorylation at Thr-45 promotes the ATP-synthesis activity.
- Protein Refseq
- NP_054861.2
- Function
- Enzyme that can either act as an ADP-sugar pyrophosphatase in absence of diphosphate or catalyze the synthesis of ATP in presence of diphosphate (PubMed:27257257).
In absence of diphosphate, hydrolyzes with similar activities various modified nucleoside diphosphates such as ADP-ribose, ADP-mannose, ADP-glucose, 8-oxo-GDP and 8-oxo-dGDP (PubMed:10567213, PubMed:10722730, PubMed:19699693, PubMed:21389046, PubMed:17052728).
Can also hydrolyze other nucleotide sugars with low activity (PubMed:19699693, PubMed:21389046).
In presence of diphosphate, mediates the synthesis of ATP in the nucleus by catalyzing the conversion of ADP-ribose to ATP and ribose 5-phosphate. Nuclear ATP synthesis takes place when dephosphorylated at Thr-45 (PubMed:27257257).
Nuclear ATP generation is required for extensive chromatin remodeling events that are energy-consuming (PubMed:27257257).
Does not play a role in U8 snoRNA decapping activity (By similarity).
Binds U8 snoRNA (By similarity).
Recommended Products
Isotype Control
Secondary Antibody
Recommended Dilution Buffer
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Antibody Magnetic Beads
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2209MZ | Recombinant Mouse Anti-Human NUDT5 Antibody | WB | Mouse antibody |
| VS3-FY2140 | Rabbit Anti-NUDT5 Recombinant Antibody (clone R65-3J-2) | WB, IHC-P | Rabbit IgG |
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