Recombinant Anti-PDGFRA Vesicular Antibody, EV Displayed (VS-0425-YC216)
CAT#: VS-0425-YC216
The Recombinant Anti-PDGFRA Vesicular Antibody, EV Displayed (VS-0425-YC216) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to PDGFRA-expressed cells or tissues. The PDGFRA is a receptor for platelet-derived growth factor family, involved in organ development and tumor progression. Mutations are linked to various cancers and disorders.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line CACO-2
Immunofluorescent staining of human cell line CACO-2 shows localization to nucleoplasm, plasma membrane & cell junctions.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/4947/1030_B8_3_selected.jpg
Normal Tissue
Figure 2 IHC staining of human bone marrow
Immunohistochemical staining of human bone marrow shows moderate cytoplasmic positivity in megakaryocytes.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/18143/ihc_selected.jpg
Normal Tissue
Figure 3 Cerebral cortex
Endothelial cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/18143/43112_B_8_5.jpg
Normal Tissue
Figure 4 Colon
Enterocytes - Fibroblasts Staining: High Intensity: Strong
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/18143/43112_A_9_3.jpg
Normal Tissue
Figure 5 Kidney
Cells in glomeruli Staining: Medium Intensity: Moderate Quantity: 75%-25%
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/18143/43112_A_7_5.jpg
Normal Tissue
Figure 6 Bone marrow
Hematopoietic cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/18143/43112_B_5_4.jpg
RNA Expression
Figure 7 RNA cell line category: Cell line enhanced (ASC diff, ASC TERT1, BJ hTERT+, fHDF/TERT166, HHSteC, HSkMC)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000134853-PDGFRA
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Recombinant Antibody
- Application
- ELISA, FC, Neut, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- PDGFRA
- Host Animal
- Human
- Antibody Isotype
- IgG
- Species Reactivity
- Human
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- z domain
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Binding Affinity
- Kd = 0.85 µg/mL
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- Platelet derived growth factor receptor alpha
- Biological Process
- Chemotaxis, Host-virus interaction
- Molecular Function
- Developmental protein, Kinase, Receptor, Transferase, Tyrosine-protein kinase
- Cellular Localization
- Nucleoplasm, Plasma membrane, Nuclear bodies, Cell Junctions, Primary cilium
- Introduction
- This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. Studies suggest that this gene plays a role in organ development, wound healing, and tumor progression. Mutations in this gene have been associated with idiopathic hypereosinophilic syndrome, somatic and familial gastrointestinal stromal tumors, and a variety of other cancers. [provided by RefSeq, Mar 2012]
- Alternative Names
- CD140a, GAS9, PDGFR2
- Gene ID
- 5156
- UniProt ID
- P16234
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Datasheet
MSDS
COA
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| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0232LY-S(P) | Human Anti-PDGFRA Recombinant Antibody (clone 2.175.3); scfv Fragment | Inhib, FC | Human scfv |
| HPAB-0233LY-S(P) | Human Anti-PDGFRA Recombinant Antibody (clone 2.451.1.1); scfv Fragment | Inhib, FC | Human scfv |
| HPAB-0234LY-S(P) | Human Anti-PDGFRA Recombinant Antibody (clone 2.449.1.3); scfv Fragment | Inhib, FC | Human scfv |
| HPAB-0235LY-S(P) | Human Anti-PDGFRA Recombinant Antibody (clone 2.998.2); scfv Fragment | Inhib, FC | Human scfv |
| HPAB-0236LY-S(P) | Human Anti-PDGFRA Recombinant Antibody (clone 2.84.3); scfv Fragment | Inhib, FC | Human scfv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0232LY-F(E) | Human Anti-PDGFRA Recombinant Antibody (clone 2.175.3); Fab Fragment | Inhib, FC | Human Fab |
| HPAB-0233LY-F(E) | Human Anti-PDGFRA Recombinant Antibody (clone 2.451.1.1); Fab Fragment | Inhib, FC | Human Fab |
| HPAB-0234LY-F(E) | Human Anti-PDGFRA Recombinant Antibody (clone 2.449.1.3); Fab Fragment | Inhib, FC | Human Fab |
| HPAB-0235LY-F(E) | Human Anti-PDGFRA Recombinant Antibody (clone 2.998.2); Fab Fragment | Inhib, FC | Human Fab |
| HPAB-0236LY-F(E) | Human Anti-PDGFRA Recombinant Antibody (clone 2.84.3); Fab Fragment | Inhib, FC | Human Fab |
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|---|---|---|---|
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| CAT | Product Name | Application | Type |
|---|---|---|---|
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| CAT | Product Name | Application | Type |
|---|---|---|---|
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| VS-0525-XY5276 | Anti-Rat PDGFRA Immunohistochemistry Kit | IHC |
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