Anti-Human CD140a Recombinant Antibody (Tovetumab) (CAT#: TAB-878)
Recombinant human monoclonal antibody expressed in CHO binding to human CD140a. Tovetumab is a monoclonal antibody designed for the treatment of cancer
Specific Inquiry
Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line CACO-2
(Immunofluorescent staining of human cell line CACO-2 shows localization to nucleoplasm, plasma membrane & cell junctions.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/4947/1030_B8_3_selected.jpg
(Immunofluorescent staining of human cell line CACO-2 shows localization to nucleoplasm, plasma membrane & cell junctions.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/4947/1030_B8_3_selected.jpg
Figure 2 IHC staining of human bone marrow
(Immunohistochemical staining of human bone marrow shows moderate cytoplasmic positivity in megakaryocytes.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/18143/ihc_selected.jpg
(Immunohistochemical staining of human bone marrow shows moderate cytoplasmic positivity in megakaryocytes.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/18143/ihc_selected.jpg
Figure 3 Cerebral cortex
(Endothelial cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/18143/43112_B_8_5.jpg
(Endothelial cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/18143/43112_B_8_5.jpg
Figure 4 Colon
(Enterocytes - Fibroblasts Staining: High Intensity: Strong)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/18143/43112_A_9_3.jpg
(Enterocytes - Fibroblasts Staining: High Intensity: Strong)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/18143/43112_A_9_3.jpg
Figure 5 Kidney
(Cells in glomeruli Staining: Medium Intensity: Moderate Quantity: 75%-25%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/18143/43112_A_7_5.jpg
(Cells in glomeruli Staining: Medium Intensity: Moderate Quantity: 75%-25%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/18143/43112_A_7_5.jpg
Figure 6 Bone marrow
(Hematopoietic cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/18143/43112_B_5_4.jpg
(Hematopoietic cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/18143/43112_B_5_4.jpg
Figure 7 RNA cell line category: Cell line enhanced (ASC diff, ASC TERT1, BJ hTERT+, fHDF/TERT166, HHSteC, HSkMC)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000134853-PDGFRA
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000134853-PDGFRA
Specifications
- Immunogen
- The details of the immunogen for this antibody are not available.
- Host Species
- Human
- Derivation
- Human
- Type
- IgG2 - kappa
- Species Reactivity
- Human
- Applications
- Suitable for use in IP, IF, FuncS, FC, Neut, ELISA, ICC and most other immunological methods.
- CAS
- 1243266-04-7
- Generic Name
- Tovetumab
- MW
- 144.8 kDa
- Related Disease
- Glioblastoma multiforme (GBM)
Product Property
- Purity
- Purity >95% by SDS-PAGE.
- Storage
- Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Target
- Alternative Names
- Tovetumab;1243266-04-7;MEDI-575;PDGFRA;platelet-derived growth factor receptor, alpha polypeptide;platelet-derived growth factor receptor alpha;CD140a;PDGFR2;PDGFR-alpha;PDGF-R-alpha;CD140a antigen;PDGFRA/BCR fusion;CD140 antigen-like family member A;plat
- Gene ID
- 5156
- UniProt ID
- P16234
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "Tovetumab"
Afuco™ Anti-PDGFRA ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-878)This product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant human monoclonal antibody expressed in CHO binding to human CD140a. It is a monoclonal antibody designed for the treatment of cancer
DrugMonitor™ Anti-Tovetumab Antibody (VS-1224-YC1230)Tovetumab is an anti-PDGFRa monoclonal antibody designed for treating cancer, studied in trials for glioblastoma multiforme and advanced solid malignancies. The DrugMonitor™ Anti-Tovetumab Antibody (VS-1224-YC1230) is an anti-drug antibody (ADA) against Tovetumab. This drug-based antibody is raised in mice immunized with the Tovetumab. The anti-Tovetumab antibody may be used in ELISA, pharmacokinetics (PK), and pharmacodynamics (PD) analyses, or serves as a reference standard in ADA assays. It also is an excellent tool for therapeutic drug monitoring, allowing to evaluate the drug efficacy and determine the drug concentration of the Tovetumab in samples.
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-192 | Anti-Human PDGF-R alpha Recombinant Antibody (Olaratumab) | IF, IP, Neut, FuncS, ELISA, FC, ICC | IgG1 - kappa |
| TAB-1063CL | Human Anti-PDGFRA Recombinant Antibody (TAB-1063CL) | FuncS | Human antibody |
| TAB-1063CL-S(P) | Human Anti-PDGFRA Recombinant Antibody; scFv Fragment (TAB-1063CL-S(P)) | ELISA | Human scFv |
| TAB-1063CL-F(E) | Human Anti-PDGFRA Recombinant Antibody; Fab Fragment (TAB-1063CL-F(E)) | ELISA | Human Fab |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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