Recombinant Mouse Anti-PRDX3 Antibody (clone 12A10C12) (CAT#: VS4-CJ88)

• Immunogen
• Recombinant Human Thioredoxin-dependent peroxide reductase, mitochondrial protein (63aa-256aa)

• Host Species
• Mouse

• Type
• Mouse IgG2b

• Specificity
• Human PRDX3

• Species Reactivity
• Human

• Clone
• 12A10C12

• Applications
• ELISA, WB, IHC, IF, FC

• Conjugate
• Unconjugated

• Purification
• Protein G purified

• Purity
• >95% as determined by SDS-PAGE

• Format
• Liquid

• Buffer
• 50% Glycerol, PBS, pH 7.3.

• Preservative
• 0.1% Sodium Azide

• Storage
• Store at -20°C or -80°C upon receipt. Avoid repeated freeze.

• Application Notes
• This antibody has been tested for use in ELISA, Western Blot (1:1000-1:5000), Immunohistochemistry (1:50-1:200), Immunofluorescence (1:50-1:200), Flow Cytometry (1:50-1:200).

• Alternative Names
• AOP1; MER5; AOP-1; PPPCD; SP-22; HBC189; SCAR32; PRO1748; prx-III

• Gene ID
• 10935

• UniProt ID
• P30048

• Long Name
• Peroxiredoxin 3

• Sequence Similarities
• Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.

• Cellular Localization
• Cytoplasm, Endosome, Mitochondrion

• Post Translation Modifications
• Phosphorylated by LRRK2; phosphorylation reduces perodixase activity.
  The enzyme can be inactivated by further oxidation of the cysteine sulfenic acid (C(P)-SOH) to sulphinic acid (C(P)-SO2H) and sulphonic acid (C(P)-SO3H) instead of its condensation to a disulfide bond.
  S-palmitoylated.

• Protein Refseq
• NP_001289201.1; NP_006784.1;

• Function
• Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides (PubMed:7733872, PubMed:17707404, PubMed:29438714, PubMed:33889951).
  Acts synergistically with MAP3K13 to regulate the activation of NF-kappa-B in the cytosol (PubMed:12492477).
  Required for the maintenance of physical strength (By similarity).

Secondary Antibody

• 2RD-A1466-YJ
• Goat Anti-Mouse IgG2b Secondary antibody

• 2RD-A1560-YJ
• Rabbit Anti-Mouse IgG2b Secondary antibody (Clone RM108)

Recommended Dilution Buffer

• MRO-0253YJ
• Reconstitution Buffer PBS

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