Recombinant Anti-RNF43 Vesicular Antibody, EV Displayed (VS-0425-YC181)
CAT#: VS-0425-YC181
The Recombinant Anti-RNF43 Vesicular Antibody, EV Displayed (VS-0425-YC181) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to RNF43-expressed cells or tissues. The RNF43 is a RING-type E3 ubiquitin ligase that negatively regulates Wnt signaling by enhancing ubiquitination and subcellular distribution alteration. Mutations are reported in various tumors.
Gene Expression
Normal Tissue
Figure 1 IHC staining of human kidney
Immunohistochemical staining of human kidney shows strong nuclear positivity in cells in tubules.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/8079/23746_A_7_5_selected.jpg
Normal Tissue
Figure 2 Cerebral cortex
Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Nuclear Glial cells Staining: High Intensity: Strong Quantity:>75% Location: Nuclear Neuronal cells Staining: High Intensity: Strong Quantity:>75% Location: Nuclear Neuropil Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/8079/23746_B_8_5.jpg
Normal Tissue
Figure 3 Colon
Endothelial cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Nuclear Glandular cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Nuclear Peripheral nerve/ganglion Staining: Medium Intensity: Moderate Quantity:>75% Location: Nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/8079/23746_A_9_3.jpg
Normal Tissue
Figure 4 Kidney
Cells in glomeruli Staining: Medium Intensity: Strong Quantity: <25% Location: Nuclear Cells in tubules Staining: High Intensity: Strong Quantity:>75% Location: Nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/8079/23746_A_7_5.jpg
Normal Tissue
Figure 5 Testis
Cells in seminiferous ducts Staining: Medium Intensity: Strong Quantity: <25% Location: Nuclear Leydig cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/8079/23746_A_6_6.jpg
Normal Tissue
Figure 6 Lymph node
Germinal center cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Nuclear Non-germinal center cells Staining: High Intensity: Strong Quantity:>75% Location: Nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/8079/23746_A_9_8.jpg
RNA Expression
Figure 7 RNA cell line category: Cell line enhanced (A549, CACO-2, Hep G2, OE19)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000108375-RNF43
❮
❯
Recombinant Antibody
- Application
- ELISA, FC, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- RNF43
- Host Animal
- Human
- Antibody Isotype
- IgG1 kappa
- Species Reactivity
- Human
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- z domain
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Binding Affinity
- Kd = 0.85 µg/mL
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- Ring finger protein 43
- Biological Process
- Ubl conjugation pathway, Wnt signaling pathway
- Molecular Function
- Developmental protein, Transferase
- Introduction
- The protein encoded by this gene is a RING-type E3 ubiquitin ligase and is predicted to contain a transmembrane domain, a protease-associated domain, an ectodomain, and a cytoplasmic RING domain. This protein is thought to negatively regulate Wnt signaling, and expression of this gene results in an increase in ubiquitination of frizzled receptors, an alteration in their subcellular distribution, resulting in reduced surface levels of these receptors. Mutations in this gene have been reported in multiple tumor cells, including colorectal and endometrial cancers. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2015]
- Alternative Names
- DKFZp781H0392, FLJ20315, URCC
- Gene ID
- 54894
- UniProt ID
- Q68DV7
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Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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See other products for "RNF43"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-327CT | Mouse Anti-RNF43 Recombinant Antibody (TAB-327CT) | WB, ELISA, FC, IHC, IP | Mouse IgG |
| TAB-327CT-S(P) | Mouse Anti-RNF43 Recombinant Antibody; scFv Fragment (TAB-327CT-S(P)) | WB, ELISA, FC, IHC, IP | Mouse scFv |
| TAB-327CT-F(E) | Mouse Anti-RNF43 Recombinant Antibody; Fab Fragment (TAB-327CT-F(E)) | WB, ELISA, FC, IHC, IP | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-328CT | Humanized Anti-RNF43 Recombinant Antibody (TAB-328CT) | WB, ELISA, FC, IHC, IP | Humanized IgG1, κ |
| TAB-328CT-S(P) | Humanized Anti-RNF43 Recombinant Antibody; scFv Fragment (TAB-328CT-S(P)) | WB, ELISA, FC, IHC, IP | Humanized scFv |
| TAB-328CT-F(E) | Humanized Anti-RNF43 Recombinant Antibody; Fab Fragment (TAB-328CT-F(E)) | WB, ELISA, FC, IHC, IP | Humanized Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-CN1185 | PE-A*02:01/Human RNF43 (ALWPWLLMAT) MHC Tetramer | FCM, IHC | |
| MHC-CN1186 | APC-A*02:01/Human RNF43 (ALWPWLLMAT) MHC Tetramer | FCM, IHC | |
| MHC-CN1187 | FITC-A*02:01/Human RNF43 (ALWPWLLMAT) MHC Tetramer | FCM, IHC | |
| MHC-CN1188 | A*02:01/Human RNF43 (ALWPWLLMAT) MHC Tetramer | FCM, IHC | |
| MHC-CN1189 | PE-A*24:02/Human RNF43 (NYQPVWLCL) MHC Tetramer | FCM, IHC |
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