Recombinant Anti-SDC1 Vesicular Antibody, EV Displayed (VS-0425-YC134)
CAT#: VS-0425-YC134
The Recombinant Anti-SDC1 Vesicular Antibody, EV Displayed (VS-0425-YC134) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to SDC1-expressed cells or tissues. The SDC1 is a transmembrane heparan sulfate proteoglycan, participating in cell proliferation and migration and interacting with the extracellular matrix. Alterations in expression are detected in various tumors.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-251 MG
Immunofluorescent staining of human cell line U-251 MG shows localization to focal adhesion sites.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/6185/if_selected.jpg
Normal Tissue
Figure 2 Cerebral cortex
Neuronal cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/6185/40538_B_8_5.jpg
Normal Tissue
Figure 3 Colon
Glandular cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/6185/40538_A_7_3.jpg
Normal Tissue
Figure 4 Testis
Pachytene spermatocytes Staining: High Intensity: Strong Quantity: 75%-25%
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/6185/40538_A_4_6.jpg
Normal Tissue
Figure 5 Placenta
Syncytiotrophoblasts - cell body Staining: High Intensity: Strong Quantity:>75% Syncytiotrophoblasts - microvilli Staining: High Intensity: Strong
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/6185/40538_A_1_7.jpg
Normal Tissue
Figure 6 Lymph node
Non-germinal center cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/6185/40538_A_7_8.jpg
RNA Expression
Figure 7 RNA cell line category: Cell line enhanced (HBEC3-KT, hTCEpi, U-251 MG, U-266/70, U-266/84)
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000115884-SDC1
❮
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Recombinant Antibody
- Application
- ELISA, FC, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- SDC1
- Host Animal
- Mouse
- Antibody Isotype
- IgG1 kappa
- Species Reactivity
- Human
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- Protein G
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- Syndecan 1
- Cellular Localization
- Focal adhesion sites
- Introduction
- The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family. The syndecans mediate cell binding, cell signaling, and cytoskeletal organization and syndecan receptors are required for internalization of the HIV-1 tat protein. The syndecan-1 protein functions as an integral membrane protein and participates in cell proliferation, cell migration and cell-matrix interactions via its receptor for extracellular matrix proteins. Altered syndecan-1 expression has been detected in several different tumor types. While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode the same protein.
- Alternative Names
- CD138, SDC, SYND1, syndecan
- Gene ID
- 6382
- UniProt ID
- P18827
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Datasheet
MSDS
COA
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| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
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| HPAB-0324-CN-F(E) | Human Anti-SDC1 Recombinant Antibody; Fab Fragment (HPAB-0324-CN-F(E)) | ELISA, FC | Humanized Fab |
| HPAB-0326-CN-F(E) | Human Anti-SDC1 Recombinant Antibody; Fab Fragment (HPAB-0326-CN-F(E)) | ELISA, FC | Humanized Fab |
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| CAT | Product Name | Application | Type |
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| NS-086CN | Human Anti-SDC1 Recombinant Antibody (NS-086CN) | ELISA | Humanized IgG |
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| NS-087CN-F(E) | Human Anti-SDC1 Recombinant Antibody; Fab Fragment (NS-087CN-F(E)) | ELISA | Humanized Fab |
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| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
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| VS-0525-XY6401 | Anti-SDC1 Immunohistochemistry Kit | IHC | |
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| VS-0525-XY6404 | Anti-Rat SDC1 Immunohistochemistry Kit | IHC |
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