Recombinant Rabbit Anti-SENP1 Antibody (clone 25H2)
CAT#: VS4-CJ112
This rabbit anti-SENP1 antibody (clone 25H2) is a product that recognizes human SENP1. The immunogen of this antibody is a synthesized peptide derived from human SENP1. The mAb has been tested for use in ELISA, Western Blot (1:500-1:2000), Immunohistochemistry (1:50-1:200), Immunofluorescence (1:50-1:200), Flow Cytometry (1:50-1:200).
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line A-431
Immunofluorescent staining of human cell line A-431 shows localization to nucleoplasm.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/11765/if_selected.jpg
RNA Expression
Figure 2 RNA cell line category: Low cell line specificity
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000079387-SENP1
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Specifications
- Immunogen
- A synthesized peptide derived from human SENP1
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human SENP1
- Species Reactivity
- Human
- Clone
- 25H2
- Applications
- ELISA, WB, IHC, IF, FC
- Conjugate
- Unconjugated
Product Property
- Purification
- Affinity chromatography
- Purity
- >95% as determined by SDS-PAGE
- Format
- Liquid
- Buffer
- 50% Glycerol, 150 mM NaCl, PBS, pH 7.4.
- Preservative
- 0.02% Sodium Azide
- Storage
- Store at -20°C or -80°C upon receipt. Avoid repeated freeze.
Applications
- Application Notes
- This antibody has been tested for use in ELISA, Western Blot (1:500-1:2000), Immunohistochemistry (1:50-1:200), Immunofluorescence (1:50-1:200), Flow Cytometry (1:50-1:200).
Target
- Alternative Names
- SuPr-2
- Gene ID
- 29843
- UniProt ID
- Q9P0U3
- Long Name
- SUMO specific peptidase 1
- Sequence Similarities
- Belongs to the peptidase C48 family.
- Cellular Localization
- Cytoplasm, Nucleus
- Protein Refseq
- NP_001254523.1; NP_001254524.1
- Function
- Protease that catalyzes two essential functions in the SUMO pathway (PubMed:10652325, PubMed:15199155, PubMed:16253240, PubMed:16553580, PubMed:21829689, PubMed:21965678, PubMed:23160374, PubMed:24943844, PubMed:25406032, PubMed:29506078).
The first is the hydrolysis of an alpha-linked peptide bond at the C-terminal end of the small ubiquitin-like modifier (SUMO) propeptides, SUMO1, SUMO2 and SUMO3 leading to the mature form of the proteins. The second is the deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins, by cleaving an epsilon-linked peptide bond between the C-terminal glycine of the mature SUMO and the lysine epsilon-amino group of the target protein. Deconjugates SUMO1 from HIPK2 (PubMed:16253240).
Deconjugates SUMO1 from HDAC1 and BHLHE40/DEC1, which decreases its transcriptional repression activity (PubMed:21829689).
Deconjugates SUMO1 from CLOCK, which decreases its transcriptional activation activity (PubMed:23160374).
Deconjugates SUMO2 from MTA1 (PubMed:21965678).
Deconjugates SUMO1 from METTL3 (PubMed:29506078).
Desumoylates CCAR2 which decreases its interaction with SIRT1 (PubMed:25406032).
Deconjugates SUMO1 from GPS2 (PubMed:24943844).
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
Isotype Control
- CAT
- Product Name
Secondary Antibody
- CAT
- Product Name
Recommended Dilution Buffer
- CAT
- Product Name
See other products for "SENP1"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2877z | Mouse Anti-SENP1 Recombinant Antibody (clone 27B1) | WB, ELISA, IF, IP | Mouse IgG1, κ |
| MRO-1376-CN | Recombinant Rabbit Anti-SENP1 Monoclonal Antibody (JG37-79) | WB, IF, IHC, FC | Rabbit IgG |
| VS3-WK474 | Rabbit Anti-SENP1 Recombinant Antibody (clone JG37-79) | WB, ELISA | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-3208 | Hi-Affi™ Recombinant Rabbit Anti-SENP1 Monoclonal Antibody (DS3208AB) | ICC, IHC-P, WB | IgG |
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