Recombinant Rabbit Anti-SENP1 Antibody (clone 25H2) (CAT#: VS4-CJ112)

• Immunogen
• A synthesized peptide derived from human SENP1

• Host Species
• Rabbit

• Type
• Rabbit IgG

• Specificity
• Human SENP1

• Species Reactivity
• Human

• Clone
• 25H2

• Applications
• ELISA, WB, IHC, IF, FC

• Conjugate
• Unconjugated

• Purification
• Affinity chromatography

• Purity
• >95% as determined by SDS-PAGE

• Format
• Liquid

• Buffer
• 50% Glycerol, 150 mM NaCl, PBS, pH 7.4.

• Preservative
• 0.02% Sodium Azide

• Storage
• Store at -20°C or -80°C upon receipt. Avoid repeated freeze.

• Application Notes
• This antibody has been tested for use in ELISA, Western Blot (1:500-1:2000), Immunohistochemistry (1:50-1:200), Immunofluorescence (1:50-1:200), Flow Cytometry (1:50-1:200).

• Alternative Names
• SuPr-2

• Gene ID
• 29843

• UniProt ID
• Q9P0U3

• Long Name
• SUMO specific peptidase 1

• Sequence Similarities
• Belongs to the peptidase C48 family.

• Cellular Localization
• Cytoplasm, Nucleus

• Protein Refseq
• NP_001254523.1; NP_001254524.1

• Function
• Protease that catalyzes two essential functions in the SUMO pathway (PubMed:10652325, PubMed:15199155, PubMed:16253240, PubMed:16553580, PubMed:21829689, PubMed:21965678, PubMed:23160374, PubMed:24943844, PubMed:25406032, PubMed:29506078).
  The first is the hydrolysis of an alpha-linked peptide bond at the C-terminal end of the small ubiquitin-like modifier (SUMO) propeptides, SUMO1, SUMO2 and SUMO3 leading to the mature form of the proteins. The second is the deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins, by cleaving an epsilon-linked peptide bond between the C-terminal glycine of the mature SUMO and the lysine epsilon-amino group of the target protein. Deconjugates SUMO1 from HIPK2 (PubMed:16253240).
  Deconjugates SUMO1 from HDAC1 and BHLHE40/DEC1, which decreases its transcriptional repression activity (PubMed:21829689).
  Deconjugates SUMO1 from CLOCK, which decreases its transcriptional activation activity (PubMed:23160374).
  Deconjugates SUMO2 from MTA1 (PubMed:21965678).
  Deconjugates SUMO1 from METTL3 (PubMed:29506078).
  Desumoylates CCAR2 which decreases its interaction with SIRT1 (PubMed:25406032).
  Deconjugates SUMO1 from GPS2 (PubMed:24943844).

Isotype Control

• MOB-208CQ
• Rabbit IgG Isotype Control Antibody

Secondary Antibody

• 2ND-059CQ
• Goat Anti-Rabbit IgG (H&L) Antibody

• 2ND-057CQ
• Donkey Anti-Rabbit IgG (H&L) Antibody

Recommended Dilution Buffer

• MRO-0253YJ
• Reconstitution Buffer PBS

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