Recombinant Anti-SIGLEC6 Vesicular Antibody, EV Displayed (VS-0425-YC645) (CAT#: VS-0425-YC645)
The Recombinant Anti-SIGLEC6 Vesicular Antibody, EV Displayed (VS-0425-YC645) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to SIGLEC6-expressed cells or tissues. SIGLEC6 is a siglec family transmembrane receptor binding glycans, with placental expression linked to preeclampsia.
Specific Inquiry
Subcellular Location and Protein Expression
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line HEL
(Immunofluorescent staining of human cell line HEL shows localization to cytosol.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/8945/1847_E5_61_selected.jpg
(Immunofluorescent staining of human cell line HEL shows localization to cytosol.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/8945/1847_E5_61_selected.jpg
Figure 2 Colon
(Mucosal lymphoid cells
Staining: Medium
Intensity: Strong
Quantity: <25%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/18198/148852_A_7_3.jpg
(Mucosal lymphoid cells
Staining: Medium
Intensity: Strong
Quantity: <25%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/18198/148852_A_7_3.jpg
Figure 3 Kidney
(Cells in tubules
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/18198/148852_A_9_5.jpg
(Cells in tubules
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/18198/148852_A_9_5.jpg
Figure 4 Placenta
(Syncytiotrophoblasts - cell body
Staining: High
Intensity: Strong
Quantity:>75%
Syncytiotrophoblasts - microvilli
Staining: Low
Intensity: Weak)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/18198/148852_A_2_7.jpg
(Syncytiotrophoblasts - cell body
Staining: High
Intensity: Strong
Quantity:>75%
Syncytiotrophoblasts - microvilli
Staining: Low
Intensity: Weak)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/18198/148852_A_2_7.jpg
Figure 5 RNA cell line category: Cell line enriched (HMC-1)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000105492-SIGLEC6/subcellular
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000105492-SIGLEC6/subcellular
Recombinant Antibody
- Application
- ELISA, FC, Inhib, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- SIGLEC6
- Host Animal
- Mouse
- Antibody Isotype
- IgG
- Species Reactivity
- Human
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- Protein A
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- Sialic acid binding Ig like lectin 6
- Biological Process
- Cell adhesion
- Cellular Localization
- Plasma membrane, Cytosol
- Introduction
- This gene encodes a member of the SIGLEC (sialic acid binding immunoglobulin-like lectin) family of proteins. The encoded transmembrane receptor binds sialyl-TN glycans and leptin. Placental expression of the encoded protein is upregulated in preeclampsia. [provided by RefSeq, Jul 2016]
- Alternative Names
- CD327, CD33L, CD33L1, OB-BP1, SIGLEC-6
- Gene ID
- 946
- UniProt ID
- O43699
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "SIGLEC6"
Select a product category from the dropdown menu below to view related products.
Please select product type
IgG Antibody Products
Fab Antibody Products
ScFv Antibody Products
ScFv-Fc Chimera Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-906 | Recombinant Anti-human SIGLEC6 Antibody | WB, FC, FuncS | IgG |
| MHH-906 | Recombinant Human Anti-human SIGLEC6 Antibody | RIA, IP, FuncS | IgG |
| HPAB-0076CQ | Mouse Anti-SIGLEC6 Recombinant Antibody (clone Mab239-90) | ELISA, FuncS, Inhib | Mouse IgG1, κ |
Customer Reviews and Q&As
There are currently no Customer reviews or questions for VS-0425-YC645. Click the button above to contact us or submit your feedback about this product.
Popular products with customers
Application: ELISA, IP, FC, FuncS, Neut, IF, ICC
Application: IF, IP, Neut, FuncS, ELISA, FC, ICC
Application: IF, IP, Neut, FuncS, ELISA, FC, ICC
Application: WB, ELISA, FuncS
Application: Neut, Inhib, FC, ELISA
Application: ELISA, IHC, FC, IP, IF, Inhib
Application: ELISA, WB
For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
Send Inquiry
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
