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SIGLEC6

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For Research Use Only. Not For Clinical Use.


This gene encodes a member of the SIGLEC (sialic acid binding immunoglobulin-like lectin) family of proteins. The encoded transmembrane receptor binds sialyl-TN glycans and leptin. Placental expression of the encoded protein is upregulated in preeclampsia. [provided by RefSeq, Jul 2016]
Protein class

CD markers

Predicted location

Membrane, Secreted (different isoforms)

Single cell type specificity

Group enriched (Syncytiotrophoblasts, Cytotrophoblasts, granulocytes)

Immune cell specificity

Group enriched (plasmacytoid DC, memory B-cell, basophil, naive B-cell)

Cell line specificity

Cell line enriched (HMC-1)

Interaction

Interacts with LEP.

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