Human Anti-SIGLEC6 (clone 239-90) scFv-Fc Chimera (CAT#: VS-0325-FY186)
The anti-SIGLEC6 scFv-Fc antibody targets SIGLEC6, a sialic acid-binding immunoglobulin-like lectin involved in immune regulation. This antibody provides specific targeting of SIGLEC6, with potential applications in studying its role in immune cell signaling, inflammation, and its potential as a therapeutic target in autoimmune and inflammatory diseases.
Specific Inquiry
Subcellular Location and Protein Expression
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line HEL
(Immunofluorescent staining of human cell line HEL shows localization to cytosol.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/8945/1847_E5_61_selected.jpg
(Immunofluorescent staining of human cell line HEL shows localization to cytosol.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/8945/1847_E5_61_selected.jpg
Figure 2 Colon
(Mucosal lymphoid cells
Staining: Medium
Intensity: Strong
Quantity: <25%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/18198/148852_A_7_3.jpg
(Mucosal lymphoid cells
Staining: Medium
Intensity: Strong
Quantity: <25%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/18198/148852_A_7_3.jpg
Figure 3 Kidney
(Cells in tubules
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/18198/148852_A_9_5.jpg
(Cells in tubules
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/18198/148852_A_9_5.jpg
Figure 4 Placenta
(Syncytiotrophoblasts - cell body
Staining: High
Intensity: Strong
Quantity:>75%
Syncytiotrophoblasts - microvilli
Staining: Low
Intensity: Weak)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/18198/148852_A_2_7.jpg
(Syncytiotrophoblasts - cell body
Staining: High
Intensity: Strong
Quantity:>75%
Syncytiotrophoblasts - microvilli
Staining: Low
Intensity: Weak)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/18198/148852_A_2_7.jpg
Figure 5 RNA cell line category: Cell line enriched (HMC-1)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000105492-SIGLEC6/subcellular
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000105492-SIGLEC6/subcellular
Specifications
- Immunogen
- Human SIGLEC-6
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Specificity
- Human SIGLEC6
- Species Reactivity
- Human
- Clone
- 239-90
- Applications
- Immunoassay
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Target
- Alternative Names
- Sialic Acid Binding Ig Like Lectin 6; Obesity-Binding Protein 1; CD33 Antigen-Like 1; CDW327; CD33L1; CD33L; OBBP1; Sialic Acid Binding Ig-Like Lectin 6
- Gene ID
- 946
- UniProt ID
- O43699
- Long Name
- Sialic Acid Binding Ig Like Lectin 6
- Sequence Similarities
- Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.
- Cellular Localization
- Cell membrane
- Post Translation Modifications
- Glycosylation at Asn103, Asn149, Asn163, and Asn233
Modification sites at PhosphoSitePlus
Glycosylation from GlyGen 5 sites, 2 N-linked glycans (1 site)
- Protein Refseq
- XP_011525835.1; XP_011525837.1; XP_011525838.1; XP_011525839.1; XP_011525840.1
- Function
- Human SIGLEC6 (Sialic acid binding Ig like lectin 6) is a cell surface receptor involved in immune regulation. Its functions are still being investigated, and it appears to play a role in certain cancers.
Recommended Products
Isotype Control
Secondary Antibody
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
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IgG Antibody Products
Fab Antibody Products
ScFv Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-906 | Recombinant Anti-human SIGLEC6 Antibody | WB, FC, FuncS | IgG |
| MHH-906 | Recombinant Human Anti-human SIGLEC6 Antibody | RIA, IP, FuncS | IgG |
| HPAB-0076CQ | Mouse Anti-SIGLEC6 Recombinant Antibody (clone Mab239-90) | ELISA, FuncS, Inhib | Mouse IgG1, κ |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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