Human Anti-SIGLEC6 (clone 239-90) scFv-Fc Chimera
CAT#: VS-0325-FY186
The anti-SIGLEC6 scFv-Fc antibody targets SIGLEC6, a sialic acid-binding immunoglobulin-like lectin involved in immune regulation. This antibody provides specific targeting of SIGLEC6, with potential applications in studying its role in immune cell signaling, inflammation, and its potential as a therapeutic target in autoimmune and inflammatory diseases.
Gene Expression
Subcellular Location and Protein Expression
Figure 1 IF staining of human cell line HEL
Immunofluorescent staining of human cell line HEL shows localization to cytosol.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/8945/1847_E5_61_selected.jpg
Normal Tissue
Figure 2 Colon
Mucosal lymphoid cells
Staining: Medium
Intensity: Strong
Quantity: <25%
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/18198/148852_A_7_3.jpg
Normal Tissue
Figure 3 Kidney
Cells in tubules
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/18198/148852_A_9_5.jpg
Normal Tissue
Figure 4 Placenta
Syncytiotrophoblasts - cell body
Staining: High
Intensity: Strong
Quantity:>75%
Syncytiotrophoblasts - microvilli
Staining: Low
Intensity: Weak
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/18198/148852_A_2_7.jpg
RNA Expression
Figure 5 RNA cell line category: Cell line enriched (HMC-1)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000105492-SIGLEC6/subcellular
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Specifications
- Immunogen
- Human SIGLEC-6
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Specificity
- Human SIGLEC6
- Species Reactivity
- Human
- Clone
- 239-90
- Applications
- Immunoassay
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Target
- Alternative Names
- Sialic Acid Binding Ig Like Lectin 6; Obesity-Binding Protein 1; CD33 Antigen-Like 1; CDW327; CD33L1; CD33L; OBBP1; Sialic Acid Binding Ig-Like Lectin 6
- Gene ID
- 946
- UniProt ID
- O43699
- Long Name
- Sialic Acid Binding Ig Like Lectin 6
- Sequence Similarities
- Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.
- Cellular Localization
- Cell membrane
- Post Translation Modifications
- Glycosylation at Asn103, Asn149, Asn163, and Asn233
Modification sites at PhosphoSitePlus
Glycosylation from GlyGen 5 sites, 2 N-linked glycans (1 site)
- Protein Refseq
- XP_011525835.1; XP_011525837.1; XP_011525838.1; XP_011525839.1; XP_011525840.1
- Function
- Human SIGLEC6 (Sialic acid binding Ig like lectin 6) is a cell surface receptor involved in immune regulation. Its functions are still being investigated, and it appears to play a role in certain cancers.
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Isotype Control
- CAT
- Product Name
Secondary Antibody
- CAT
- Product Name
See other products for "SIGLEC6"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-906 | Recombinant Anti-human SIGLEC6 Antibody | WB, FC, FuncS | IgG |
| MHH-906 | Recombinant Human Anti-human SIGLEC6 Antibody | RIA, IP, FuncS | IgG |
| HPAB-0076CQ | Mouse Anti-SIGLEC6 Recombinant Antibody (clone Mab239-90) | ELISA, FuncS, Inhib | Mouse IgG1, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-906-F(E) | Recombinant Anti-human SIGLEC6 Antibody Fab Fragment | FC, WB, FuncS | Fab |
| MHH-906-F(E) | Recombinant Human Anti-human SIGLEC6 Antibody Fab Fragment | ELISA, WB, Dot, FuncS | Fab |
| HPAB-0076CQ-F(E) | Mouse Anti-SIGLEC6 Recombinant Antibody (clone Mab239-90); Fab Fragment | ELISA, FuncS, Inhib | Mouse Fab, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-906-S(P) | Recombinant Anti-human SIGLEC6 Antibody scFv Fragment | WB, IF, FuncS | scFv |
| MHH-906-S(P) | Recombinant Human Anti-human SIGLEC6 Antibody scFv Fragment | WB, ELISA, IHC, FuncS | scFv |
| HPAB-0076CQ-S(P) | Mouse Anti-SIGLEC6 Recombinant Antibody (clone Mab239-90); scFv Fragment | ELISA, FuncS, Inhib | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC645 | Recombinant Anti-SIGLEC6 Vesicular Antibody, EV Displayed (VS-0425-YC645) | ELISA, FC, Inhib, Cell-uptake |
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