Recombinant Mouse Anti-SOX2 Antibody (VS4-CJ123) (CAT#: VS4-CJ123)
This mouse anti-SOX2 antibody is a product that recognizes human, porcine, mouse, rat SOX2. The immunogen of this antibody is recombinant full length protein (319aa) of mouse Sox2. The mAb has been tested for use in ELISA, Western Blot (1:500-1:5000).
Specific Inquiry
Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line U-251 MG
(Immunofluorescent staining of human cell line U-251 MG shows localization to nucleoplasm.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/45725/if_selected.jpg
(Immunofluorescent staining of human cell line U-251 MG shows localization to nucleoplasm.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/45725/if_selected.jpg
Figure 2 IF staining of human cell line HEK 293
(Immunofluorescent staining of human cell line HEK 293 shows localization to nucleoplasm.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/62851/1273_B4_7_selected.jpg
(Immunofluorescent staining of human cell line HEK 293 shows localization to nucleoplasm.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/62851/1273_B4_7_selected.jpg
Figure 3 High expression in cerebral cortex
(Glial cells Staining: Medium Intensity: Strong Quantity: <25% Location: Nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/79745/167827_B_9_5.jpg
(Glial cells Staining: Medium Intensity: Strong Quantity: <25% Location: Nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/79745/167827_B_9_5.jpg
Figure 4 Esophagus
(Squamous epithelial cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/79745/167827_B_6_1.jpg
(Squamous epithelial cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/79745/167827_B_6_1.jpg
Figure 5 Colon
(Peripheral nerve/ganglion Staining: Low Intensity: Weak Quantity: 75%-25% Location: Nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/79745/167827_A_7_3.jpg
(Peripheral nerve/ganglion Staining: Low Intensity: Weak Quantity: 75%-25% Location: Nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/79745/167827_A_7_3.jpg
Figure 6 RNA cell line category: Cell line enhanced (AF22, HAP1, NTERA-2, U-251 MG)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000181449-SOX2
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000181449-SOX2
Specifications
- Immunogen
- Recombinant full length protein (319aa) of mouse Sox2.
- Host Species
- Mouse
- Type
- Mouse IgG2b
- Specificity
- Human, Porcine, Mouse, Rat SOX2
- Species Reactivity
- Human, Porcine, Mouse, Rat
- Applications
- ELISA, WB
- Conjugate
- Unconjugated
Product Property
- Purification
- Affinity purified
- Purity
- >95% as determined by SDS-PAGE
- Format
- Liquid
- Buffer
- 50% Glycerol, 0.1M Tris-Glycine (150 mM NaCl), pH 7.4.
- Preservative
- 0.2% Sodium Azide
- Storage
- Store at -20°C or -80°C upon receipt. Avoid repeated freeze.
Applications
- Application Notes
- This antibody has been tested for use in ELISA, Western Blot (1:500-1:5000).
Target
- Alternative Names
- ANOP3; MCOPS3
- Gene ID
- 6657
- UniProt ID
- P48431
- Long Name
- SRY-box transcription factor 2
- Cellular Localization
- Cytoplasm, Nucleus
- Post Translation Modifications
- Sumoylation inhibits binding on DNA and negatively regulates the FGF4 transactivation.
Methylation at Lys-42 and Lys-117 is necessary for the regulation of SOX2 proteasomal degradation.
- Protein Refseq
- NP_003097.1
- Function
- Transcription factor that forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206 (By similarity).
Binds to the proximal enhancer region of NANOG (By similarity).
Critical for early embryogenesis and for embryonic stem cell pluripotency (PubMed:18035408).
Downstream SRRT target that mediates the promotion of neural stem cell self-renewal (By similarity).
Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation (By similarity).
May function as a switch in neuronal development (By similarity).
Recommended Products
Secondary Antibody
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "SOX2"
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2438z | Mouse Anti-SOX2 Recombinant Antibody (clone 44A5) | WB, ELISA, IHC | Mouse IgG2b, κ |
| ZG-108R | Mouse Anti-SOX2 Recombinant Antibody (ZG-108R) | WB | Mouse IgG |
| ZG-109R | Mouse Anti-SOX2 Recombinant Antibody (ZG-109R) | WB, ELISA | Mouse IgG |
| ZG-110R | Mouse Anti-SOX2 Recombinant Antibody (ZG-110R) | WB, ELISA, IHC, IF | Mouse IgG |
| VS3-CJ83 | Mouse Anti-SOX2 Recombinant Antibody (VS3-CJ83) | WB, ELISA | Mouse IgG |
Rabbit Monoclonal Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-3377 | Hi-Affi™ Recombinant Rabbit Anti-SOX2 Monoclonal Antibody (DS3377AB) | ICC, IHC-P, WB, sELISA | IgG |
| MOR-0107-FY | Rabbit Anti-SOX2 Recombinant Antibody (clone AFY0078) | ICC, IHC-P, WB | Rabbit IgG |
MHC Tetramer for Cancer
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-CN0275 | APC-A*02:01/Human SOX2 (SMYLPGAEV) MHC Tetramer | FCM | |
| MHC-CN0276 | PE-A*02:01/Human SOX2 (SMYLPGAEV) MHC Tetramer | FCM | |
| MHC-CN0303 | APC-A*02:01/Human SOX2 (TLMKKDKYTL) MHC Tetramer | FCM | |
| MHC-CN0304 | PE-A*02:01/Human SOX2 (TLMKKDKYTL) MHC Tetramer | FCM |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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