Recombinant Rabbit Anti-THBD Antibody (clone 15C7) (CAT#: VS4-CJ135)
This rabbit anti-THBD antibody (clone 15C7) is a product that recognizes human THBD. The immunogen of this antibody is a synthesized peptide derived from human THBD. The mAb has been tested for use in ELISA, Immunohistochemistry (1:50-1:200).
Specific Inquiry
Subcellular Location and Protein Expression
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line U-2 OS
(Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoplasm & cytosol.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2982/29_E4_2_selected.jpg
(Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoplasm & cytosol.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2982/29_E4_2_selected.jpg
Figure 2 IHC staining of human placenta
(Immunohistochemical staining of human placenta shows strong membranous positivity in trophoblastic cells.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2982/ihc_selected.jpg
(Immunohistochemical staining of human placenta shows strong membranous positivity in trophoblastic cells.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2982/ihc_selected.jpg
Figure 3 IHC staining of human placenta
(Immunohistochemical staining of human placenta shows luminal positivity.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2425/ihc_selected.jpg
(Immunohistochemical staining of human placenta shows luminal positivity.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2425/ihc_selected.jpg
Figure 4 IF staining of human cell line A-431
(Immunofluorescent staining of human cell line A-431 shows localization to nucleoplasm & cytosol.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2982/30_E4_1_red_green.jpg
(Immunofluorescent staining of human cell line A-431 shows localization to nucleoplasm & cytosol.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2982/30_E4_1_red_green.jpg
Figure 5 Colon
(Endothelial cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2425/6389_A_7_3.jpg
(Endothelial cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2425/6389_A_7_3.jpg
Figure 6 Placenta
(Trophoblastic cells
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2425/6389_A_3_7.jpg
(Trophoblastic cells
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2425/6389_A_3_7.jpg
Figure 7 RNA cell line category: Cell line enhanced (ASC diff, CAPAN-2, EFO-21, HaCaT, hTCEpi, OE19, THP-1)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000178726-THBD
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000178726-THBD
Specifications
- Immunogen
- A synthesized peptide derived from human THBD
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human THBD
- Species Reactivity
- Human
- Clone
- 15C7
- Applications
- ELISA, IHC
- Conjugate
- Unconjugated
Product Property
- Purification
- Affinity chromatography
- Purity
- >95% as determined by SDS-PAGE
- Format
- Liquid
- Buffer
- 50% Glycerol, 150 mM NaCl, PBS, pH 7.4.
- Preservative
- 0.02% Sodium Azide
- Storage
- Store at -20°C or -80°C upon receipt. Avoid repeated freeze.
Applications
- Application Notes
- This antibody has been tested for use in ELISA, Immunohistochemistry (1:50-1:200).
Target
- Alternative Names
- TM; THRM; AHUS6; BDCA3; CD141; BDCA-3; THPH12
- Gene ID
- 7056
- UniProt ID
- P07204
- Long Name
- Thrombomodulin
- Cellular Localization
- Membrane
- Post Translation Modifications
- N-glycosylated.
The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.
- Protein Refseq
- NP_000352.1
- Function
- Thrombomodulin is a specific endothelial cell receptor that forms a 1:1 stoichiometric complex with thrombin. This complex is responsible for the conversion of protein C to the activated protein C (protein Ca). Once evolved, protein Ca scissions the activated cofactors of the coagulation mechanism, factor Va and factor VIIIa, and thereby reduces the amount of thrombin generated.
Recommended Products
Isotype Control
Secondary Antibody
Recommended Dilution Buffer
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| NAB-1329-VHH | Recombinant Anti-Mouse Thbd VHH Single Domain Antibody | IHC, ICC, FC, FA, FUNC | Llama VHH |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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