Recombinant Anti-TLR9 Vesicular Antibody, EV Displayed (VS-0425-YC447)
CAT#: VS-0425-YC447
The Recombinant Anti-TLR9 Vesicular Antibody, EV Displayed (VS-0425-YC447) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to TLR9-expressed cells or tissues. The TLR9 is a Toll-like receptor recognizing microbial DNA, critical for innate immune system activation.
Gene Expression
RNA Expression
Figure 1 RNA cell line category: Group enriched (Daudi, RPMI-8226, U-698)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000239732-TLR9
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Recombinant Antibody
- Application
- ELISA, FC, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- TLR9
- Host Animal
- Mouse
- Antibody Isotype
- IgG
- Species Reactivity
- Human
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- Protein A
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- Toll like receptor 9
- Biological Process
- Immunity, Inflammatory response, Innate immunity
- Molecular Function
- Receptor
- Introduction
- The protein encoded by this gene is a member of the Toll-like receptor (TLR) family, which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. Studies in mice and human indicate that this receptor mediates cellular response to unmethylated CpG dinucleotides in bacterial DNA to mount an innate immune response.
- Alternative Names
- CD289
- Gene ID
- 54106
- UniProt ID
- Q9NR96
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Related Signaling Pathways
NLR Signaling Pathway
TLR Signaling Pathway
Downloadable Resources
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Datasheet
MSDS
COA
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| CAT | Product Name | Application | Type |
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|---|---|---|---|
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