Recombinant Anti-human TLR9 Intrabody [(D-Arg)9] (CAT#: IAB-B043(A))
Recombinant anti-TLR9 intrabody linked to (D-Arg)9 works within cells and binds specifically to human TLR9, expressed in E. coli cells. Intracellular antibodiess expressed inside the ER block transitory protein functions by inhibiting the translocation of the protein from the ER to its subcellular destination.
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Custom Production
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RNA Expression
Figure 1 RNA cell line category: Group enriched (Daudi, RPMI-8226, U-698)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000239732-TLR9
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000239732-TLR9
Specifications
- Immunogen
- human Toll-like receptor 9
- Host Species
- human
- Type
- scFv-(D-Arg)9
- Cell Penetrating Peptide
- (D-Arg)9
It has been proven that polyarginine peptides composed of nine arginine amino acids (Arg-9) are able to translocate across cells very efficiently. This raises the question if molecular dynamics simulations would show a similar pathway for this highly hydrophilic and charged peptide as predicted for the Tat peptide. The simplicity of Arg-9 over other CPPs also helps isolate the role of the Arg sidechain on the translocation without the effect of other sidechains. Therefore, in this work we study computationally the translocation of Arg-9 through a lipid bilayer and show that the translocation mechanism is the same as for the Tat peptide.
- Species Reactivity
- human
- Applications
- Products can be used for: Fluorescence-activated cell sorting; Immunocytochemistry; Functional studies
Product Property
- Purity
- >98% by SDS-PAGE and HPLC analysis
- Storage
- 4 °C, -20°C if preferred
Target
Related Resources
NLR Signaling Pathway
TLR Signaling Pathway
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Extracellular Vesicle (EV) Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| IAB-B043(G) | Recombinant Anti-human TLR9 Intrabody [+36 GFP] | ELISA, ICC, FuncS | scFv-(+36GFP) |
| IAB-B043(T) | Recombinant Anti-human TLR9 Intrabody [Tat] | PCA, Neut, FuncS | scFv-Tat |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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