Recombinant Anti-human TLR9 Intrabody [Tat]
CAT#: IAB-B043(T)
Recombinant anti-TLR9 intrabody in fusion with HIV Tat works within cells to bind human TLR9, expressed in E. coli cells. Intracellular antibodiess expressed inside the ER block transitory protein functions by inhibiting the translocation of the protein from the ER to its subcellular destination.
Gene Expression
RNA Expression
Figure 1 RNA cell line category: Group enriched (Daudi, RPMI-8226, U-698)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000239732-TLR9
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Specifications
- Immunogen
- human Toll-like receptor 9
- Host Species
- human
- Type
- scFv-Tat
- Cell Penetrating Peptide
- TAT
TAT was able to deliver different proteins, such as horseradish peroxidase and RNase A across cell membrane into the cytoplasm in different cell lines in vitro. The size range of proteins with effective delivery is from 30kDa to 120-150kDa. In one study, TAT-fused proteins are rapidly internalized by lipid raft−dependent macropinocytosis using a transducible TAT−Cre recombinase reporter assay on live cells. In another study, a TAT-fused protein was delivered into mitochondria of breast cancer cells and decreased the survival of breast cancer cells, which showed capability of TAT-fusion proteins to modulate mitochondrial function and cell survival. However, very few in vivo studies have succeeded. In one study, in vivo delivery of TAT- or penetratin-crosslinked Fab fragments yielded varied organ distributions and an overall increase in organ retention, which showed tissue localization.
- Species Reactivity
- human
- Applications
- Formats of immunological tests: Protein fragment complementation; Neutralization; Functional studies
Product Property
- Purity
- >95% as determined by analysis by SDS-PAGE
- Storage
- ≥1 year at -20°C. If the reconstituted antibody cannot be used within two weeks, it should be aliquoted into smaller vials and stored at -20°C
Target
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Related Signaling Pathways
NLR Signaling Pathway
TLR Signaling Pathway
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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MSDS
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| HPAB-0131-YC | Mouse Anti-TLR9 Recombinant Antibody (HPAB-0131-YC) | ELISA, FC, IHC | Mouse IgG2a, κ |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| IAB-B043(A) | Recombinant Anti-human TLR9 Intrabody [(D-Arg)9] | FACS, ICC, FuncS | scFv-(D-Arg)9 |
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| CAT | Product Name | Application | Type |
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| BRD-0591MZ | Chicken Anti-TLR9 Polyclonal IgY | WB | Chicken antibody |
| CAT | Product Name | Application | Type |
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| MOR-3588 | Rabbit Anti-TLR9 Recombinant Antibody (clone DS3588AB) | ICC, IF, WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0130-YC-S(P) | Mouse Anti-TLR9 Recombinant Antibody; scFv Fragment (HPAB-0130-YC-S(P)) | ELISA, FC, IHC | Mouse scFv |
| HPAB-0131-YC-S(P) | Mouse Anti-TLR9 Recombinant Antibody; scFv Fragment (HPAB-0131-YC-S(P)) | ELISA, FC, IHC | Mouse scFv |
| HPAB-N0395-YC-S(P) | Mouse Anti-TLR9 Recombinant Antibody; scFv Fragment (HPAB-N0395-YC-S(P)) | ELISA, FC | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0130-YC-F(E) | Mouse Anti-TLR9 Recombinant Antibody; Fab Fragment (HPAB-0130-YC-F(E)) | ELISA, FC, IHC | Mouse Fab |
| HPAB-0131-YC-F(E) | Mouse Anti-TLR9 Recombinant Antibody; Fab Fragment (HPAB-0131-YC-F(E)) | ELISA, FC, IHC | Mouse Fab |
| HPAB-N0395-YC-F(E) | Mouse Anti-TLR9 Recombinant Antibody; Fab Fragment (HPAB-N0395-YC-F(E)) | ELISA, FC | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0225-XY214 | CytoStream™ Rat Anti-TLR9 Recombinant Antibody (VS-0225-XY214) | FC | Rat IgG2a, kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC447 | Recombinant Anti-TLR9 Vesicular Antibody, EV Displayed (VS-0425-YC447) | ELISA, FC, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY7315 | Anti-TLR9 Immunohistochemistry Kit | IHC | |
| VS-0525-XY7316 | Anti-Mouse TLR9 Immunohistochemistry Kit | IHC |
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