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TLR9
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family, which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. Studies in mice and human indicate that this receptor mediates cellular response to unmethylated CpG dinucleotides in bacterial DNA to mount an innate immune response.
Protein class
CD markers, FDA approved drug targets, Human disease related genes
Predicted location
Membrane
Single cell type specificity
Group enriched (B-cells, Plasma cells, Paneth cells, Microglial cells)
Immune cell specificity
Immune cell enriched (plasmacytoid DC)
Cell line specificity
Group enriched (Daudi, RPMI-8226, U-698)
Interaction
Monomer and homodimer. Exists as a monomer in the absence of unmethylated cytidine-phosphate-guanosine (CpG) ligand. Proteolytic processing of an insertion loop (Z-loop) is required for homodimerization upon binding to the unmethylated CpG ligand leading to its activation (By similarity). Interacts with MYD88 via their respective TIR domains (By similarity). Interacts with BTK (PubMed:17932028). Interacts (via transmembrane domain) with UNC93B1. Interacts with CD300LH; the interaction may promote full activation of TLR9-triggered innate responses (By similarity). Interacts with CNPY3 and HSP90B1; this interaction is required for proper folding in the endoplasmic reticulum (PubMed:20865800). Interacts with SMPDL3B (By similarity).
Molecular function
Receptor
More Types Infomation
Related Signaling Pathways
NLR Signaling Pathway
TLR Signaling Pathway
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- Derivation: Phage display library
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: ICC, IF, WB
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- Species Reactivity: Human
- Application: ELISA, ICC/IF, WB
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1, κ
- Application: WB, ELISA, FC, ICC, IF, IHC, IP, Dot, FuncS
- Mouse Anti-TLR9 Recombinant Antibody; scFv Fragment (HPAB-N0395-YC-S(P)) (HPAB-N0395-YC-S(P))
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- Species Reactivity: Human
- Type: Mouse scFv
- Application: ELISA, FC
- Mouse Anti-TLR9 Recombinant Antibody; Fab Fragment (HPAB-0131-YC-F(E)) (HPAB-0131-YC-F(E))
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- Species Reactivity: Human
- Type: Mouse Fab
- Application: ELISA, FC, IHC
- Mouse Anti-TLR9 Recombinant Antibody; Fab Fragment (HPAB-0130-YC-F(E)) (HPAB-0130-YC-F(E))
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- Species Reactivity: Human
- Type: Mouse Fab
- Application: ELISA, FC, IHC
- Mouse Anti-TLR9 Recombinant Antibody (HPAB-0131-YC) (HPAB-0131-YC)
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- Species Reactivity: Human
- Type: Mouse IgG2a, κ
- Application: ELISA, FC, IHC
- Mouse Anti-TLR9 Recombinant Antibody (HPAB-0130-YC) (HPAB-0130-YC)
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- Species Reactivity: Human
- Type: Mouse IgG2a, κ
- Application: ELISA, FC, IHC
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG2a
- Application: WB, ELISA
- Mouse Anti-TLR9 Recombinant Antibody; Fab Fragment (HPAB-N0395-YC-F(E)) (HPAB-N0395-YC-F(E))
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- Species Reactivity: Human
- Type: Mouse Fab
- Application: ELISA, FC
- Recombinant Anti-human TLR9 Intrabody [Tat] (IAB-B043(T))
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- Species Reactivity: human
- Type: scFv-Tat
- Application: PCA, Neut, FuncS
- Recombinant Anti-human TLR9 Intrabody [+36 GFP] (IAB-B043(G))
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- Species Reactivity: human
- Type: scFv-(+36GFP)
- Application: ELISA, ICC, FuncS
- Recombinant Anti-human TLR9 Intrabody [(D-Arg)9] (IAB-B043(A))
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- Species Reactivity: human
- Type: scFv-(D-Arg)9
- Application: FACS, ICC, FuncS
- Chicken Anti-TLR9 Polyclonal IgY (BRD-0591MZ)
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- Species Reactivity: Human, Mouse, Rat
- Type: Chicken antibody
- Application: WB
- Mouse Anti-TLR9 Recombinant Antibody (HPAB-N0395-YC) (HPAB-N0395-YC)
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- Species Reactivity: Human
- Type: Mouse IgG2a, κ
- Application: ELISA, FC
- Mouse Anti-TLR9 Recombinant Antibody; scFv Fragment (HPAB-0131-YC-S(P)) (HPAB-0131-YC-S(P))
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- Species Reactivity: Human
- Type: Mouse scFv
- Application: ELISA, FC, IHC
- Mouse Anti-TLR9 Recombinant Antibody; scFv Fragment (HPAB-0130-YC-S(P)) (HPAB-0130-YC-S(P))
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- Species Reactivity: Human
- Type: Mouse scFv
- Application: ELISA, FC, IHC
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