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TLR9

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Anti-TLR9 Recombinant Antibody Products

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For Research Use Only. Not For Clinical Use.


TLR9 is an endosomal receptor expressed on B cells, macrophages, and dendritic cells. It recognizes unmethylated CpG motifs in bacterial and viral DNA. When TLR9 binds to CpG - containing DNA, it recruits the MyD88 adaptor protein. This initiates a signaling cascade that activates NF - κB and other transcription factors, leading to the production of cytokines such as interleukin - 6 (IL - 6), interleukin - 12 (IL - 12), and type I interferons. TLR9 - mediated immune responses are important for the defense against intracellular pathogens and also play a role in the activation of the adaptive immune system.
Protein class

CD markers, FDA approved drug targets, Human disease related genes

Predicted location

Membrane

Single cell type specificity

Group enriched (B-cells, Plasma cells, Paneth cells, Microglial cells)

Immune cell specificity

Immune cell enriched (plasmacytoid DC)

Cell line specificity

Group enriched (Daudi, RPMI-8226, U-698)

Interaction

Monomer and homodimer. Exists as a monomer in the absence of unmethylated cytidine-phosphate-guanosine (CpG) ligand. Proteolytic processing of an insertion loop (Z-loop) is required for homodimerization upon binding to the unmethylated CpG ligand leading to its activation (By similarity). Interacts with MYD88 via their respective TIR domains (By similarity). Interacts with BTK (PubMed:17932028). Interacts (via transmembrane domain) with UNC93B1. Interacts with CD300LH; the interaction may promote full activation of TLR9-triggered innate responses (By similarity). Interacts with CNPY3 and HSP90B1; this interaction is required for proper folding in the endoplasmic reticulum (PubMed:20865800). Interacts with SMPDL3B (By similarity).

Molecular function

Receptor

More Types Infomation
Related Signaling Pathways
NLR Signaling Pathway NLR Signaling Pathway
TLR Signaling Pathway TLR Signaling Pathway
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