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For Research Use Only. Not For Clinical Use.
Intracellular
Cell type enhanced (Langerhans cells, monocytes, Basal respiratory cells)
Low immune cell specificity
Cell line enhanced (MCF7)
Forms heterodimers either with the pro-apoptotic protein BAX or the anti-apoptotic protein BCL2 (By similarity). Interacts with PLEKHN1 (PubMed:29531808). [BH3-interacting domain death agonist]: Interacts with humanin; forms fibers with humanin which results in BID conformational changes and sequestering of BID into the fibers, preventing BID activation. [BH3-interacting domain death agonist p15]: Interacts with ITCH (PubMed:20392206). Interacts with humanin; the interaction prevents BID-induced apoptosis (PubMed:15661737). Interacts with MTCH2 (By similarity).