Anti-CAMK2D Products

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For Research Use Only. Not For Clinical Use.

Anti-CAMK2D recombinant antibodies are a valuable tool for researchers in cardiovascular studies. CAMK2D, the dominant cardiac isoform of the CAMKII complex, is a key integrator of cardiac calcium handling and an orchestrator of pathologic remodeling in heart disease. Creative Biolabs provides the highest quality recombinant antibodies to help you study arrhythmias, heart failure, and develop new treatments for cardiovascular disease.

CAMK2D: A Central Mediator of Cardiac Disease

Calcium/Calmodulin-Dependent Protein Kinase II Delta (CAMK2D) is the major CAMKII isoform expressed in the heart. It is an important calcium signal transducer, playing a fundamental role in normal excitation-contraction coupling in the heart. During pathological conditions such as chronic stress (e.g., heart failure, myocardial infarction), CAMK2D becomes pathologically hyperactive. The kinase aberrantly phosphorylates key cardiac calcium-handling proteins (e.g., ryanodine receptor, phospholamban) causing arrhythmias, cardiomyocyte death, and adverse cardiac remodeling. Thus, the development of pharmacologic strategies to inhibit CAMK2D is an important and active area of therapeutic development.

Alternative Names

CAMKD

Background

CAMK2D (Calcium/Calmodulin Dependent Protein Kinase II Delta) is a Protein Coding gene. Diseases associated with CAMK2D include Dilated Cardiomyopathy. Pathways associated with CAMK2D include RET signaling and Salivary secretion. Gene Ontology (GO) annotations that overlap with this gene include protein homodimerization activity and protein kinase activity. An important paralog of this gene is CAMK2B.

Anti-CAMK2D rAb Products

Creative Biolabs' anti-CAMK2D recombinant antibodies (rAbs) have been engineered to the highest specificity standards, carefully validated to detect the delta isoform with no cross-reactivity with the other CAMK2 isoforms. These reagents have been optimized for Western Blot detection in cardiac lysates as well as IHC staining on heart sections. All of our rAbs have been validated to ensure you receive the highest quality, customizable antibody for your cardiovascular research. We also provide an antibody to the oxidized, constitutively active form of the protein.

Table 1. Featured anti-CAMK2D recombinant antibody products at Creative Biolabs.

Customer Reviews

rAb Production

Creative Biolabs uses state-of-the-art production methods to support your cutting edge cardiovascular research. Our anti-CAMK2D recombinant antibodies are expressed in optimized systems that yield a reagent that closely recognizes native kinase.

Featured Anti-CAMK2D Recombinant Antibody Production Platforms
Fig.1 Milligram-scale anti-CAMK2D recombinant antibody production.

Fig.2 Gram-scale anti-CAMK2D recombinant antibody production.

rAb Modalities

Creative Biolabs is committed to empowering your research with the most innovative and customizable solutions possible. Our anti-CAMK2D recombinant antibodies are available in a range of customizable formats to fit your experimental needs and continue to enable researchers from around the world to study this key driver of heart disease.

Fig.3 Full-length anti-CAMK2D recombinant antibody production and modalities.

Discover the specific role of CAMK2D in cardiac pathology using Creative Biolabs recombinant antibodies. Stringent validation and unmatched performance have become hallmarks of our portfolio, making our products the ideal tools for your research into cardiac arrhythmias and heart failure. Let our expertise accelerate your next discovery. Contact one of our specialists today.